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ML 281 - ≥98%(HPLC), high purity , CAS No.1404437-62-2
Basic Description Synonyms N-[2-(3,4-Dihydro-3-oxo-2-quinoxalinyl)-4-(1-methylethyl)phenyl]-2-thiophenecarboxamide；N-(4-isopropyl-2-(3-oxo-3,4-dihydroquinoxalin-2-yl)phenyl)thiophene-2-carboxamide Specifications & Purity ≥98%(HPLC) Biochemical and Physiological Mechanisms Inhibitor of the serine/threonine kinase STK33 (IC50= 14 nM). Exhibits >700-fold selectivity for STK33 over the structurally related protein kinase A (PKA); also exhibits 550-fold selectivity over Aurora kinase B. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name N-[2-(3-oxo-4H-quinoxalin-2-yl)-4-propan-2-ylphenyl]thiophene-2-carboxamide INCHI InChI=1S/C22H19N3O2S/c1-13(2)14-9-10-16(24-21(26)19-8-5-11-28-19)15(12-14)20-22(27)25-18-7-4-3-6-17(18)23-20/h3-13H,1-2H3,(H,24,26)(H,25,27) InChi Key HWOYIOLMBQSTQS-UHFFFAOYSA-N Canonical SMILES CC(C)C1=CC(=C(C=C1)NC(=O)C2=CC=CS2)C3=NC4=CC=CC=C4NC3=O Isomeric SMILES CC(C)C1=CC(=C(C=C1)NC(=O)C2=CC=CS2)C3=NC4=CC=CC=C4NC3=O PubChem CID 53377448 Molecular Weight 389.47
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 38.95, Max Conc. mM: 100
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F2204485