ML 339 - 98%(mixture of isomers), high purity , CAS No.2080300-49-6

Item Number

M288061

Grouped product items
SKU	Size	Availability	Price
M288061-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$48.90
M288061-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$118.90
M288061-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$130.90
M288061-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$341.90
M288061-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$550.90

Potent and selective hCXCR6 antagonist

Basic Description

Specifications & Purity	≥98%, mixture of isomers
Biochemical and Physiological Mechanisms	Potent and selective hCXCR6 antagonist (IC50= 140 nM); 100-fold less active at the murine CXCR6 receptor (IC50= 18μM). Exhibits selectivity over CXCR5, CXCR4, CCR6 and APJ receptors (IC50>79μM).
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	ML339 is a selective CXCR6 antagonist with an IC50 of 140 nM. ML339 has IC50 >79 μM for CXCR5, CXCR4, CCR6, and Apelin receptors (APJ). ML339 has the potential to advance the field of prostate cancer research

Associated Targets(Human)

CXCR4 Tclin C-X-C chemokine receptor type 4 (3338 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CCR6 Tchem C-C chemokine receptor type 6 (388 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CXCR6 Tchem C-X-C chemokine receptor type 6 (264 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	N-[(1S,5R)-9-[2-(2-chloroanilino)-2-oxoethyl]-9-azabicyclo[3.3.1]nonan-3-yl]-3,4,5-trimethoxybenzamide
INCHI	InChI=1S/C26H32ClN3O5/c1-33-22-11-16(12-23(34-2)25(22)35-3)26(32)28-17-13-18-7-6-8-19(14-17)30(18)15-24(31)29-21-10-5-4-9-20(21)27/h4-5,9-12,17-19H,6-8,13-15H2,1-3H3,(H,28,32)(H,29,31)/t17?,18-,19+
InChi Key	SSPYAPRDKNCABY-YQQQUEKLSA-N
Canonical SMILES	COC1=CC(=CC(=C1OC)OC)C(=O)NC2CC3CCCC(C2)N3CC(=O)NC4=CC=CC=C4Cl
Isomeric SMILES	COC1=CC(=CC(=C1OC)OC)C(=O)NC2C[C@H]3CCC[C@@H](C2)N3CC(=O)NC4=CC=CC=C4Cl
Alternate CAS	2579689-83-9
PubChem CID	71768224
Molecular Weight	502.00

Certificates

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10 results found

Lot Number	Certificate Type	Date	Item
A2417462	Certificate of Analysis	Dec 21, 2023	M288061
A2417463	Certificate of Analysis	Dec 21, 2023	M288061
A2417464	Certificate of Analysis	Dec 21, 2023	M288061
A2417465	Certificate of Analysis	Dec 21, 2023	M288061
A2417466	Certificate of Analysis	Dec 21, 2023	M288061
A2417467	Certificate of Analysis	Dec 21, 2023	M288061
A2417468	Certificate of Analysis	Dec 21, 2023	M288061
A2417469	Certificate of Analysis	Dec 21, 2023	M288061
A2417470	Certificate of Analysis	Dec 21, 2023	M288061
A2417471	Certificate of Analysis	Dec 21, 2023	M288061

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Basic Description