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ML 349 - 98%, high purity , CAS No.890819-86-0
Selective and reversible lysophospholipase 2 (LYPLA2) inhibitor
Basic Description Synonyms (5,5-Dioxido-4H-thieno[3,2-c][1]benzothiopyran-2-yl)[4-(4-methoxyphenyl)-1-piperazinyl]methanone;ML 349; ML-349; (5,5-Dioxo-4H-thieno[4,5-c]thiochromen-2-yl)-[4-(4-methoxyphenyl)piperazin-1-yl]methanone Specifications & Purity ≥98% Biochemical and Physiological Mechanisms Selective and reversible lysophospholipase 2 (LYPLA2) inhibitor (IC50= 144 nM). Displays selectively over LYPLA1 and 20 other serine hydrolases (IC50values are >3000 and >10,000 nM respectively). Storage Temp Store at -20°C Shipped In Ice chest + Ice pads
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name (5,5-dioxo-4H-thieno[3,2-c]thiochromen-2-yl)-[4-(4-methoxyphenyl)piperazin-1-yl]methanone INCHI InChI=1S/C23H22N2O4S2/c1-29-18-8-6-17(7-9-18)24-10-12-25(13-11-24)23(26)20-14-16-15-31(27,28)21-5-3-2-4-19(21)22(16)30-20/h2-9,14H,10-13,15H2,1H3 InChi Key YVIJPELUPZUEJX-UHFFFAOYSA-N Canonical SMILES COC1=CC=C(C=C1)N2CCN(CC2)C(=O)C3=CC4=C(S3)C5=CC=CC=C5S(=O)(=O)C4 Isomeric SMILES COC1=CC=C(C=C1)N2CCN(CC2)C(=O)C3=CC4=C(S3)C5=CC=CC=C5S(=O)(=O)C4 PubChem CID 16193817 Molecular Weight 454.56
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 9.09, Max Conc. mM: 20
Safety and Hazards(GHS) RIDADR NONHforallmodesoftransport
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F2310383