Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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M286620-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $39.90 | |
M286620-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $119.90 | |
M286620-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $141.90 | |
M286620-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $419.90 | |
M286620-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $590.90 |
Selective PAR4antagonist
Synonyms | 1-Methyl-5-nitro-3-phenyl-1H-indole-2-methanol | DTXSID90353779 | 1h-indole-2-methanol, 1-methyl-5-nitro-3-phenyl- | ML 354;ML-354 | STK783537 | EU-0047807 | HY-19973 | SR-01000083946 | Oprea1_017031 | 1-methyl-2-hydroxymethyl-3-phenyl-5-nitroindole | VU0 |
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Specifications & Purity | Moligand™, ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | Selective PAR4antagonist (IC50= 140 nM). Exhibits 70-fold selectivity for PAR4over PAR1. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ANTAGONIST |
Mechanism of action | Antagonist of PAR4 |
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IUPAC Name | (1-methyl-5-nitro-3-phenylindol-2-yl)methanol |
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INCHI | InChI=1S/C16H14N2O3/c1-17-14-8-7-12(18(20)21)9-13(14)16(15(17)10-19)11-5-3-2-4-6-11/h2-9,19H,10H2,1H3 |
InChi Key | GNJUKVGDCUKDLF-UHFFFAOYSA-N |
Canonical SMILES | CN1C2=C(C=C(C=C2)[N+](=O)[O-])C(=C1CO)C3=CC=CC=C3 |
Isomeric SMILES | CN1C2=C(C=C(C=C2)[N+](=O)[O-])C(=C1CO)C3=CC=CC=C3 |
Alternate CAS | 89159-60-4 |
PubChem CID | 752812 |
MeSH Entry Terms | ML354 compound;VU0099704 |
Molecular Weight | 282.29 |
Enter Lot Number to search for COA:
Solubility | Solvent:DMSO, Max Conc. mg/mL: 28.23, Max Conc. mM: 100 |
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1. Wen W, Young SE, Duvernay MT, Schulte ML, Nance KD, Melancon BJ, Engers J, Locuson 2nd CW, Wood MR, Daniels JS et al.. (2014) Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354.. Bioorg Med Chem Lett, 24 (19): (4708-13). [PMID:25176330] [10.1021/op500134e] |