Selective TRPML agonist. Induces TRPML1, 2 and 3-mediated Ca 2+ release from lysosomes in vitro . Does not activate TRPM2, TRPV2, TRPA1, TRPV3, TRPC6 channels. Cell-permeable.
ML-SA1 is a potent and selective cell permeable agonist of lysosomal mucolipin
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
ACTIVATOR
Mechanism of action
Activator of TRPML1;Activator of TRPML2;Activator of TRPML3
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Application
ML-SA1 has been used as a transient receptor potential cation channel mucolipin 1 (TRPML1/ML1) agonist.
1.Shen D, Wang X, Li X, Zhang X, Yao Z, Dibble S, Dong XP, Yu T, Lieberman AP, Showalter HD et al.. (2012) Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release.. Nat Commun, 3 (3):(731). [PMID:22415822]
2.Wang Y et al.. (2018) Degradation of TRPML1 in Neurons Reduces Neuron Survival in Transient Global Cerebral Ischemia.. Oxid Med Cell Longev, 2018 (4612727). [PMID:30662583]
3.Wang H et al.. (2020) Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis.. Autophagy, 16 (9):(1683-1696). [PMID:31826695]
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K2218509