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ML-SA1 - 95% (HPLC), high purity , CAS No.332382-54-4, Activator of TRPML1;Activator of TRPML2;Activator of TRPML3

Moligand™
≥95%(HPLC)

CAS#: 332382-54-4
Formula: C₂₂H₂₂N₂O₃
Molecular Weight: 362.42
PubChem CID: 2880983

Item Number

M169636

Grouped product items
SKU	Size	Availability	Price
M169636-5mg	5mg	In stock	$44.90
M169636-25mg	25mg	In stock	$184.90
M169636-50mg	50mg	In stock	$303.90
M169636-100mg	100mg	In stock	$547.90
M169636-250mg	250mg	In stock	$1,231.90

Selective TRPML agonist

View related series

TRPML1 Activator TRPML2 Activator TRPML3 Activator

Basic Description

Synonyms	332382-54-4\|ML SA1\|ML-SA1\|2-[2-oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione\|2-(2-oxo-2-(2,2,4-Trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl)isoindoline-1,3-dione\|2-[2-oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1-yl)
Specifications & Purity	95% (HPLC)
Storage Temp	Store at -20°C
Shipped In	Dry ice
Grade	Moligand™
Action Type	ACTIVATOR
Mechanism of action	Activator of TRPML1;Activator of TRPML2;Activator of TRPML3
Product Description	Application ML-SA1 has been used as a transient receptor potential cation channel mucolipin 1 (TRPML1/ML1) agonist.

Associated Targets

MCOLN2 Tchem Mucolipin-2 0 Activities

Discover Target: MCOLN2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MCOLN1 Tchem Mucolipin-1 1 Activities

Discover Target: MCOLN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MCOLN3 Tchem Mucolipin-3 0 Activities

Discover Target: MCOLN3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-[2-oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1-yl)ethyl]isoindole-1,3-dione
INCHI	InChI=1S/C22H22N2O3/c1-14-12-22(2,3)24(18-11-7-6-8-15(14)18)19(25)13-23-20(26)16-9-4-5-10-17(16)21(23)27/h4-11,14H,12-13H2,1-3H3
InChi Key	KDDHBJICVBONAX-UHFFFAOYSA-N
Canonical SMILES	CC1CC(N(C2=CC=CC=C12)C(=O)CN3C(=O)C4=CC=CC=C4C3=O)(C)C
Isomeric SMILES	CC1CC(N(C2=CC=CC=C12)C(=O)CN3C(=O)C4=CC=CC=C4C3=O)(C)C
WGK Germany	3
PubChem CID	2880983
Molecular Weight	362.42

CAS Registry No.

332382-54-4

PubChem CID

2880983

ChEMBL Ligand

CHEMBL1527280

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
K2218509	Certificate of Analysis	Sep 01, 2022	M169636
K2218510	Certificate of Analysis	Sep 01, 2022	M169636
K2218511	Certificate of Analysis	Sep 01, 2022	M169636
K2218512	Certificate of Analysis	Sep 01, 2022	M169636
K2218608	Certificate of Analysis	Sep 01, 2022	M169636

Safety and Hazards(GHS)

Signal	Danger
Hazard Statements	H301:Toxic if swallowed H410:Very toxic to aquatic life with long lasting effects
Precautionary Statements	P273:Avoid release to the environment. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER/doctor/... P501:Dispose of contents/container to ...
WGK Germany	3

References

1. Shen D, Wang X, Li X, Zhang X, Yao Z, Dibble S, Dong XP, Yu T, Lieberman AP, Showalter HD et al.. (2012) Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release.. Nat Commun, 3 (3): (731). [PMID:22415822]
2. Wang Y et al.. (2018) Degradation of TRPML1 in Neurons Reduces Neuron Survival in Transient Global Cerebral Ischemia.. Oxid Med Cell Longev, 2018 (4612727). [PMID:30662583]
3. Wang H et al.. (2020) Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis.. Autophagy, 16 (9): (1683-1696). [PMID:31826695]

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