Inhibitor of nucleotide binding oligomerization domain containing 1;Inhibitor of nucleotide binding oligomerization domain containing 2
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
ML130 (Nodinitib-1) is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM, inhibits NF-κB activation, exhibits 36-fold selectivity over NOD2
1.Correa RG, Khan PM, Askari N, Zhai D, Gerlic M, Brown B, Magnuson G, Spreafico R, Albani S, Sergienko E et al.. (2011) Discovery and characterization of 2-aminobenzimidazole derivatives as selective NOD1 inhibitors.. Chem Biol, 18 (7):(825-32). [PMID:21802003]
2.Khan PM, Correa RG, Divlianska DB, Peddibhotla S, Sessions EH, Magnuson G, Brown B, Suyama E, Yuan H, Mangravita-Novo A et al.. (2011) Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation.. ACS Med Chem Lett, 2 (10):(780-785). [PMID:22003428]
3.Wu J et al.. (2022) Peptidoglycan-Mediated Bone Marrow Autonomic Neuropathy Impairs Hematopoietic Stem/Progenitor Cells via a NOD1-Dependent Pathway in db/db Mice.. Stem Cells Int, 2022 (4249843). [PMID:35966130]
4.Liu FY et al.. (2020) The Role of the NOD1/Rip2 Signaling Pathway in Myocardial Remodeling in Spontaneously Hypertensive Rats.. Med Sci Monit, 26 (e924748). [PMID:32855380]
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D2102124