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ML213 - 10mM in DMSO, high purity , CAS No.489402-47-3
KV7.2 and KV7.4 channel opener
Basic Description Synonyms ML213 | 489402-47-3 | N-mesitylbicyclo[2.2.1]heptane-2-carboxamide | ML 213 | ML-213 | N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-2-carboxamide | CHEMBL1703636 | CID-3111211 | N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-6-carboxamide | Bicyclo[2.2.1]heptane-2-carbox Specifications & Purity Moligand™, 10mM in DMSO Biochemical and Physiological Mechanisms Selective KV7.2 (KCNQ2) and KV7.4 (KCNQ4) channel opener (EC50values are 230 and 510 nM for KV7.2 and KV7.4 respectively). Displays > 80-fold selectivity against KV7.1, KV7.3 and KV7.5 in a thallium-based fluorescence assay. Hyperpolarizes resting membran Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Grade Moligand™
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-2-carboxamide INCHI InChI=1S/C17H23NO/c1-10-6-11(2)16(12(3)7-10)18-17(19)15-9-13-4-5-14(15)8-13/h6-7,13-15H,4-5,8-9H2,1-3H3,(H,18,19) InChi Key SIQGKPGBLYKQBB-UHFFFAOYSA-N Canonical SMILES CC1=CC(=C(C(=C1)C)NC(=O)C2CC3CCC2C3)C Isomeric SMILES CC1=CC(=C(C(=C1)C)NC(=O)C2CC3CCC2C3)C WGK Germany 3 PubChem CID 3111211 Molecular Weight 257.37
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
H413: May cause long lasting harmful effects to aquatic life
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
WGK Germany 3
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