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ML348 - ≥98％, high purity , CAS No.899713-86-1
Selective and reversible lysophospholipase 1 (LYPLA1) inhibitor
Basic Description Synonyms N-(2-chloro-5-(trifluoromethyl)phenyl)-2-(4-(furan-2-carbonyl)piperazin-1-yl)acetamide | BCP18861 | MFCD05123530 | CS-5993 | SR-01000595170-5 | STL419865 | AS-16715 | SR-01000595170-3 | AKOS002133531 | ML-348(ML348) | BDBM207991 | SR-01000595170-4 | MLS00 Specifications & Purity ≥98% Biochemical and Physiological Mechanisms Selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50= 210 nM). Exhibits 14-fold selectivity for LYPLA1 over LYPLA2. Also selective over a panel of ~30 other serine hydrolases. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name N-[2-chloro-5-(trifluoromethyl)phenyl]-2-[4-(furan-2-carbonyl)piperazin-1-yl]acetamide INCHI InChI=1S/C18H17ClF3N3O3/c19-13-4-3-12(18(20,21)22)10-14(13)23-16(26)11-24-5-7-25(8-6-24)17(27)15-2-1-9-28-15/h1-4,9-10H,5-8,11H2,(H,23,26) InChi Key OXKNHBBDOIMFFQ-UHFFFAOYSA-N Canonical SMILES C1CN(CCN1CC(=O)NC2=C(C=CC(=C2)C(F)(F)F)Cl)C(=O)C3=CC=CO3 Isomeric SMILES C1CN(CCN1CC(=O)NC2=C(C=CC(=C2)C(F)(F)F)Cl)C(=O)C3=CC=CO3 PubChem CID 3238952 Molecular Weight 415.79
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 41.58, Max Conc. mM: 100
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J2128265