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ML372 - 99%, high purity , CAS No.1331745-61-9

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ML372 - 99%, high purity , CAS No.1331745-61-9

≥99%

CAS#: 1331745-61-9
Formula: C₁₈H₂₀N₂O₄S
Molecular Weight: 360.43
PubChem CID: 46907666

Item Number

M648249

Grouped product items
SKU	Size	Availability	Price
M648249-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$390.90
M648249-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$620.90
M648249-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,250.90

View related series

Cell Cycle/DNA Damage DNA/RNA Synthesis

Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	ML372 inhibits survival motor neuron ( SMN ) protein ubiquitination, increases SMN protein stability without affecting mRNA expression. ML372 improves spinal muscular atrophy (SMA) in mice. ML372 is brain penetrant and has a reasonable exposure and half-l
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	ML372 inhibits survival motor neuron ( SMN ) protein ubiquitination, increases SMN protein stability without affecting mRNA expression. ML372 improves spinal muscular atrophy (SMA) in mice. ML372 is brain penetrant and has a reasonable exposure and half-life in vivo. Form:Solid

Associated Targets(Human)

Caco-2 (12174 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Liver (3974 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Luciferase (58 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Luciferin 4-monooxygenase (66902 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Brain (1 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasma (328 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	1-[5-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
INCHI	InChI=1S/C18H20N2O4S/c21-17(22)12-4-6-20(7-5-12)18-19-11-16(25-18)13-2-3-14-15(10-13)24-9-1-8-23-14/h2-3,10-12H,1,4-9H2,(H,21,22)
InChi Key	HAVNRFQWAXTDTI-UHFFFAOYSA-N
Canonical SMILES	C1COC2=C(C=C(C=C2)C3=CN=C(S3)N4CCC(CC4)C(=O)O)OC1
Isomeric SMILES	C1COC2=C(C=C(C=C2)C3=CN=C(S3)N4CCC(CC4)C(=O)O)OC1
PubChem CID	46907666
Molecular Weight	360.43

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Chemical and Physical Properties

Solubility	DMSO : 33.33 mg/mL (92.47 mM; ultrasonic and warming and heat to 60°C)

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ML372 - 99%, high purity , CAS No.1331745-61-9

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Related Documents

Solution Calculators

Molarity Calculator

Dilution Calculator

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