ML385 - 99%, high purity , CAS No.846557-71-9, Inhibitor of nuclear factor; erythroid 2 like 2

Item Number
M304758
Grouped product items
SKUSizeAvailabilityPrice Qty
M304758-5mg
5mg
In stock
$44.90
M304758-25mg
25mg
In stock
$147.90
M304758-100mg
100mg
In stock
$376.90

Nrf2 inhibitor; phenotypically lethal

Basic Description

Specifications & PurityMoligand™, ≥99%
Biochemical and Physiological MechanismsNrf2 inhibitor. Blocks Nrf2 downstream target gene expression. Enhances cytotoxic effects ofdoxorubicin orTaxol in non-small cell lung cancer (NSCLC). Demonstrates selectivity for NSCLC cells with KEAP1 mutations.
Storage TempStore at 2-8°C
Shipped InWet ice
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of nuclear factor; erythroid 2 like 2
Product Description

ML385 is a specific nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor with an IC50 of 1.9 μM.

Associated Targets(Human)

NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PTH1R Tclin Parathyroid hormone receptor (47172 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLB Tchem DNA polymerase beta (23632 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
L3MBTL1 Tchem Lethal(3)malignant brain tumor-like protein 1 (14536 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SMN1 Tchem Survival motor neuron protein (34246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SMAD3 Tchem Mothers against decapentaplegic homolog 3 (68039 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MBNL1 Tbio Muscleblind-like protein 1 (34431 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Cruzipain (33337 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NS1 Nonstructural protein 1 (33327 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488191809
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488191809
IUPAC Name 2-(1,3-benzodioxol-5-yl)-N-[5-methyl-4-[1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl]-1,3-thiazol-2-yl]acetamide
INCHI InChI=1S/C29H25N3O4S/c1-17-5-3-4-6-22(17)28(34)32-12-11-20-15-21(8-9-23(20)32)27-18(2)37-29(31-27)30-26(33)14-19-7-10-24-25(13-19)36-16-35-24/h3-10,13,15H,11-12,14,16H2,1-2H3,(H,30,31,33)
InChi Key LINHYWKZVCNAMQ-UHFFFAOYSA-N
Canonical SMILES CC1=CC=CC=C1C(=O)N2CCC3=C2C=CC(=C3)C4=C(SC(=N4)NC(=O)CC5=CC6=C(C=C5)OCO6)C
Isomeric SMILES CC1=CC=CC=C1C(=O)N2CCC3=C2C=CC(=C3)C4=C(SC(=N4)NC(=O)CC5=CC6=C(C=C5)OCO6)C
PubChem CID 1383822
Molecular Weight 511.59

Certificates

Certificate of Analysis(COA)

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21 results found

Lot NumberCertificate TypeDateItem
H2429550Certificate of AnalysisJul 25, 2024 M304758
H2429547Certificate of AnalysisJul 25, 2024 M304758
H2429545Certificate of AnalysisJul 25, 2024 M304758
H2106164Certificate of AnalysisMay 11, 2024 M304758
E2421319Certificate of AnalysisMay 08, 2024 M304758
E2421318Certificate of AnalysisMay 08, 2024 M304758
K2302468Certificate of AnalysisOct 20, 2023 M304758
K2302436Certificate of AnalysisOct 20, 2023 M304758
K2302435Certificate of AnalysisOct 20, 2023 M304758
E23291205Certificate of AnalysisMay 17, 2023 M304758
E23291204Certificate of AnalysisMay 17, 2023 M304758
E23291197Certificate of AnalysisMay 17, 2023 M304758
E23291189Certificate of AnalysisMay 17, 2023 M304758
B2309557Certificate of AnalysisNov 28, 2022 M304758
B2309543Certificate of AnalysisNov 28, 2022 M304758
B2309540Certificate of AnalysisNov 28, 2022 M304758
B2309485Certificate of AnalysisNov 28, 2022 M304758
B2309481Certificate of AnalysisNov 28, 2022 M304758
H2205473Certificate of AnalysisJun 15, 2022 M304758
H2205474Certificate of AnalysisJun 15, 2022 M304758
H2205475Certificate of AnalysisJun 15, 2022 M304758

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Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 25.58, Max Conc. mM: 50

Safety and Hazards(GHS)

RIDADR NONHforallmodesoftransport

Related Documents

Citations of This Product

1. Fan Wenbo, Zhou Jianwu.  (2023)  Icariside II Suppresses Ferroptosis to Protect Against MPP+-Induced Parkinson's Disease through Keap1/Nrf2/GPX4 Signaling.  CHINESE JOURNAL OF PHYSIOLOGY,  66  (6): (437).  [PMID:38149556] [10.4103/cjop.CJOP-D-23-00107]
2. Bing-hao Lin, Run-xun Ma, Jing-tao Wu, Shi-qi Du, Yi-yun Lv, Hao-nan Yu, Wei Zhang, Shu-ming Mao, Guang-yao Liu, Yi-tian Bu, Zi-hao Chen, Chen Jin, Zong-yi Wu, Lei Yang.  (2023)  Cinnamaldehyde Alleviates Bone Loss by Targeting Oxidative Stress and Mitochondrial Damage via the Nrf2/HO-1 Pathway in BMSCs and Ovariectomized Mice.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  71  (45): (17362–17378).  [PMID:37917162] [10.1021/acs.jafc.3c03501]
3. Yue Tang, Yueyue Kang, Xinru Zhang, Caiyi Cheng.  (2023)  Mesenchymal stem cell exosomes as nanotherapeutics for dry age-related macular degeneration.  JOURNAL OF CONTROLLED RELEASE,  357  (356).  [PMID:37028452] [10.1016/j.jconrel.2023.04.003]
4. Hengju Ge, Jiaxin Li, Yang Xu, Jiahong Xie, Naymul Karim, Fujie Yan, Jianling Mo, Wei Chen.  (2023)  Ameliorative effect of Fructus Gardeniae against lipotoxicity associated hepatocytes injury through activating Nrf2 signaling pathway.  Food Bioscience,  53  (102596).  [PMID:] [10.1016/j.fbio.2023.102596]
5. Yun Zhang, Maihuan Wang, Kebin Zhang, Junze Zhang, Xinpu Yuan, Guijun Zou, Zhen Cao, Chaojun Zhang.  (2022)  6′-O-Galloylpaeoniflorin attenuates Helicobacter pylori-associated gastritis via modulating Nrf2 pathway.  INTERNATIONAL IMMUNOPHARMACOLOGY,  111  (109122).  [PMID:35964411] [10.1016/j.intimp.2022.109122]

References

1. Singh A, Misra V, Thimmulappa RK, Lee H, Ames S, Hoque MO, Herman JG, Baylin SB, Sidransky D, Gabrielson E et al..  (2006)  Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer..  PLoS Med,  (10): (e420).  [PMID:17020408] [10.1021/op500134e]
2. Ohta T, Iijima K, Miyamoto M, Nakahara I, Tanaka H, Ohtsuji M, Suzuki T, Kobayashi A, Yokota J, Sakiyama T et al..  (2008)  Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth..  Cancer Res,  68  (5): (1303-9).  [PMID:18316592] [10.1021/op500134e]
3. Shibata T, Kokubu A, Gotoh M, Ojima H, Ohta T, Yamamoto M, Hirohashi S.  (2008)  Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer..  Gastroenterology,  135  (4): (1358-1368, 1368.e1-4).  [PMID:18692501] [10.1021/op500134e]
4. Shibata T, Ohta T, Tong KI, Kokubu A, Odogawa R, Tsuta K, Asamura H, Yamamoto M, Hirohashi S.  (2008)  Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy..  Proc Natl Acad Sci USA,  105  (36): (13568-73).  [PMID:18757741] [10.1021/op500134e]
5. Solis LM, Behrens C, Dong W, Suraokar M, Ozburn NC, Moran CA, Corvalan AH, Biswal S, Swisher SG, Bekele BN et al..  (2010)  Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features..  Clin Cancer Res,  16  (14): (3743-53).  [PMID:20534738] [10.1021/op500134e]
6. Konstantinopoulos PA, Spentzos D, Fountzilas E, Francoeur N, Sanisetty S, Grammatikos AP, Hecht JL, Cannistra SA.  (2011)  Keap1 mutations and Nrf2 pathway activation in epithelial ovarian cancer..  Cancer Res,  71  (15): (5081-9).  [PMID:21676886] [10.1021/op500134e]
7. Tsvetkova E, Goss GD.  (2012)  Drug resistance and its significance for treatment decisions in non-small-cell lung cancer..  Curr Oncol,  19  (Suppl 1): (S45-51).  [PMID:22787410] [10.1021/op500134e]
8. Tian Y, Wu K, Liu Q, Han N, Zhang L, Chu Q, Chen Y.  (2016)  Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer..  J Hematol Oncol,  (1): (83).  [PMID:27601007] [10.1021/op500134e]
9. Singh A, Venkannagari S, Oh KH, Zhang YQ, Rohde JM, Liu L, Nimmagadda S, Sudini K, Brimacombe KR, Gajghate S et al..  (2016)  Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors..  ACS Chem Biol,  11  (11): (3214-3225).  [PMID:27552339] [10.1021/op500134e]
10. Fan Wenbo, Zhou Jianwu.  (2023)  Icariside II Suppresses Ferroptosis to Protect Against MPP+-Induced Parkinson's Disease through Keap1/Nrf2/GPX4 Signaling.  CHINESE JOURNAL OF PHYSIOLOGY,  66  (6): (437).  [PMID:38149556] [10.4103/cjop.CJOP-D-23-00107]
11. Bing-hao Lin, Run-xun Ma, Jing-tao Wu, Shi-qi Du, Yi-yun Lv, Hao-nan Yu, Wei Zhang, Shu-ming Mao, Guang-yao Liu, Yi-tian Bu, Zi-hao Chen, Chen Jin, Zong-yi Wu, Lei Yang.  (2023)  Cinnamaldehyde Alleviates Bone Loss by Targeting Oxidative Stress and Mitochondrial Damage via the Nrf2/HO-1 Pathway in BMSCs and Ovariectomized Mice.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  71  (45): (17362–17378).  [PMID:37917162] [10.1021/acs.jafc.3c03501]
12. Yue Tang, Yueyue Kang, Xinru Zhang, Caiyi Cheng.  (2023)  Mesenchymal stem cell exosomes as nanotherapeutics for dry age-related macular degeneration.  JOURNAL OF CONTROLLED RELEASE,  357  (356).  [PMID:37028452] [10.1016/j.jconrel.2023.04.003]
13. Hengju Ge, Jiaxin Li, Yang Xu, Jiahong Xie, Naymul Karim, Fujie Yan, Jianling Mo, Wei Chen.  (2023)  Ameliorative effect of Fructus Gardeniae against lipotoxicity associated hepatocytes injury through activating Nrf2 signaling pathway.  Food Bioscience,  53  (102596).  [PMID:] [10.1016/j.fbio.2023.102596]
14. Yun Zhang, Maihuan Wang, Kebin Zhang, Junze Zhang, Xinpu Yuan, Guijun Zou, Zhen Cao, Chaojun Zhang.  (2022)  6′-O-Galloylpaeoniflorin attenuates Helicobacter pylori-associated gastritis via modulating Nrf2 pathway.  INTERNATIONAL IMMUNOPHARMACOLOGY,  111  (109122).  [PMID:35964411] [10.1016/j.intimp.2022.109122]

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