MLCK inhibitor peptide 18 TFA, CAS No.224579-74-2(free basis), Inhibitor of myosin light chain kinase

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    Item Number
    M287814
    Grouped product items
    SKUSizeAvailabilityPrice Qty
    M287814-1mg
    1mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $64.90
    M287814-5mg
    5mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $129.90
    M287814-10mg
    10mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $199.90
    M287814-25mg
    25mg
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    Production requires sourcing of materials. We appreciate your patience and understanding.
    $399.90
    M287814-50mg
    50mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $639.90

    Selective inhibitor of myosin light chain kinase

    Basic Description

    Product NameMLCK inhibitor peptide 18 TFA, CAS No.224579-74-2(free basis)
    GradeMoligand™
    Product Description

    MLCK inhibitor peptide 18 TFA is a myosin light chain kinase (MLCK) inhibitor with an IC50 of 50 nM, and inhibits CaM kinase II only at 4000-fold higher concentrations.

    Specifications & PurityMoligand™, ≥98%
    Biochemical and Physiological MechanismsSelective competitive inhibitor of myosin light chain kinase (IC50= 50 nM). Displays 4000-fold selectivity over CaM kinase II and does not inhibit PKA. Cell permeable.
    SequenceArg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH2
    Action TypeINHIBITOR
    Mechanism of actionInhibitor of myosin light chain kinase

    Associated Targets(Human)

    MYLK Tchem Myosin light chain kinase, smooth muscle (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    Product Specifications

    Storage TempStore at -20°C,Desiccated
    Shipped InIce chest + Ice pads
    CAS224579-74-2(free basis)

    Certificates

    Certificate of Analysis(COA)

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    10 results found

    Lot NumberCertificate TypeDateItem
    G2430151Certificate of AnalysisApr 19, 2024 M287814
    G2430152Certificate of AnalysisApr 19, 2024 M287814
    G2430154Certificate of AnalysisApr 19, 2024 M287814
    G2430155Certificate of AnalysisApr 19, 2024 M287814
    G2430157Certificate of AnalysisApr 19, 2024 M287814
    G2430158Certificate of AnalysisApr 19, 2024 M287814
    G2430159Certificate of AnalysisApr 19, 2024 M287814
    G2430160Certificate of AnalysisApr 19, 2024 M287814
    G2430161Certificate of AnalysisApr 19, 2024 M287814
    G2430169Certificate of AnalysisApr 19, 2024 M287814

    Genetic information

    Reference
    • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
    • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
    • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
    • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
    • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
    • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
    • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
    • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
    • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
    • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

    Related Documents

    References

    1. Lukas TJ, Mirzoeva S, Slomczynska U, Watterson DM.  (1999)  Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge..  J Med Chem,  42  (5): (910-9).  [PMID:10072688] [10.1021/op500134e]

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