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MLN0905 - 97%, high purity , CAS No.1228960-69-7, Inhibitor of polo like kinase 1

Item Number
M126487
Grouped product items
SKUSizeAvailabilityPrice Qty
M126487-2mg
2mg
In stock
$85.90
M126487-5mg
5mg
In stock
$177.90
M126487-10mg
10mg
In stock
$300.90
M126487-25mg
25mg
In stock
$677.90
M126487-50mg
50mg
In stock
$959.90
M126487-100mg
100mg
In stock
$1,728.90
M126487-250mg
250mg
In stock
$3,888.90
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Cell Cycle/DNA Damage polo like kinase 1 Inhibitor Polo-like Kinase (PLK)

Basic Description

Synonyms2-(5-(3-(DIMETHYLAMINO)PROPYL)-2-METHYLPYRIDIN-3-YLAMINO)-9-(TRIFLUOROMETHYL)-5H-BENZO[B]PYRIMIDO[4,5-D]AZEPINE-6(7H)-THIONE | 2-[[5-[3-(dimethylamino)propyl]-2-methylpyridin-3-yl]amino]-9-(trifluoromethyl)-5,7-dihydropyrimido[5,4-d][1]benzazepine-6-thion
Specifications & PurityMoligand™, ≥97%
Biochemical and Physiological Mechanisms

MLN0905, a small-molecule PLK1 inhibitor, induces antitumor responses in human models of diffuse large B-cell lymphoma. PLK1 inhibition leads to pharmacodynamic pHisH3 modulation and significant antitumor activity in multiple DLBCL models

Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of polo like kinase 1

Associated Targets(Human)

PLK1 Tchem Serine/threonine-protein kinase PLK1 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A-375 (9258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-29 (80576 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-116 (91556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI-H460 (60772 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488201272
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488201272
IUPAC Name 2-[[5-[3-(dimethylamino)propyl]-2-methylpyridin-3-yl]amino]-9-(trifluoromethyl)-5,7-dihydropyrimido[5,4-d][1]benzazepine-6-thione
INCHI InChI=1S/C24H25F3N6S/c1-14-19(9-15(12-28-14)5-4-8-33(2)3)31-23-29-13-16-10-21(34)30-20-11-17(24(25,26)27)6-7-18(20)22(16)32-23/h6-7,9,11-13H,4-5,8,10H2,1-3H3,(H,30,34)(H,29,31,32)
InChi Key CODBZFJPKJDNDT-UHFFFAOYSA-N
Canonical SMILES CC1=C(C=C(C=N1)CCCN(C)C)NC2=NC=C3CC(=S)NC4=C(C3=N2)C=CC(=C4)C(F)(F)F
Isomeric SMILES CC1=C(C=C(C=N1)CCCN(C)C)NC2=NC=C3CC(=S)NC4=C(C3=N2)C=CC(=C4)C(F)(F)F
PubChem CID 46235922
Molecular Weight 486.56

Certificates

Certificate of Analysis(COA)

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18 results found

Lot NumberCertificate TypeDateItem
K2322393Certificate of AnalysisAug 21, 2023 M126487
K2322392Certificate of AnalysisAug 21, 2023 M126487
K2322391Certificate of AnalysisAug 21, 2023 M126487
K2322390Certificate of AnalysisAug 21, 2023 M126487
F2307498Certificate of AnalysisMay 08, 2023 M126487
F2308093Certificate of AnalysisMay 08, 2023 M126487
F2308092Certificate of AnalysisMay 08, 2023 M126487
F2308089Certificate of AnalysisMay 08, 2023 M126487
F2308088Certificate of AnalysisMay 08, 2023 M126487
F2307488Certificate of AnalysisMay 08, 2023 M126487
F2307497Certificate of AnalysisMay 08, 2023 M126487
F2307496Certificate of AnalysisMay 08, 2023 M126487
F2307495Certificate of AnalysisMay 08, 2023 M126487
F2307494Certificate of AnalysisMay 08, 2023 M126487
F2307493Certificate of AnalysisMay 08, 2023 M126487
F2307492Certificate of AnalysisMay 08, 2023 M126487
F2307491Certificate of AnalysisMay 08, 2023 M126487
F2307490Certificate of AnalysisMay 08, 2023 M126487

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Related Documents

 SDS

 Specification Sheet

References

1. Duffey MO, Vos TJ, Adams R, Alley J, Anthony J, Barrett C, Bharathan I, Bowman D, Bump NJ, Chau R et al..  (2012)  Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of Polo-like kinase 1 (MLN0905)..  J Med Chem,  55  (1): (197-208).  [PMID:22070629] [10.1021/op500134e]

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