Basic Description

Synonyms	N-[(1,1'-Biphenyl)-4-ylsulfonyl]-D-phenylalanine
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Matrix metalloproteinase inhibitor of MMP-2/MMP-9. Synergizes with TNF-α to induce apoptosis in cancer cells. Active in vitro .
Storage Temp	Store at 2-8°C,Desiccated
Shipped In	Wet ice
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Associated Targets(Human)

MMP2 Tchem 72 kDa type IV collagenase (0 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mmp2 Matrix metalloproteinase-2 (12 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IUPAC Name	3-phenyl-2-[(4-phenylphenyl)sulfonylamino]propanoic acid
INCHI	InChI=1S/C21H19NO4S/c23-21(24)20(15-16-7-3-1-4-8-16)22-27(25,26)19-13-11-18(12-14-19)17-9-5-2-6-10-17/h1-14,20,22H,15H2,(H,23,24)
InChi Key	JBYHBQIDTNHWJF-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C(C=C1)CC(C(=O)O)NS(=O)(=O)C2=CC=C(C=C2)C3=CC=CC=C3
Isomeric SMILES	C1=CC=C(C=C1)CC(C(=O)O)NS(=O)(=O)C2=CC=C(C=C2)C3=CC=CC=C3
PubChem CID	4222
Molecular Weight	381.44

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Solubility	Soluble in DMSO to 25 mM

1. Wang JB et al.. (2022) CDK5RAP3 acts as a tumour suppressor in gastric cancer through the infiltration and polarization of tumour-associated macrophages.. Cancer Gene Ther, [PMID:35999359]
2. Osaki T et al.. (2018) Cooperative Effects of Vascular Angiogenesis and Lymphangiogenesis.. Regen Eng Transl Med, 4 (3): (120-132). [PMID:30417074]
3. Hu Q et al.. (2020) MMP7 damages the integrity of the renal tubule epithelium by activating MMP2/9 during ischemia-reperfusion injury.. J Mol Histol, 51 (6): (685-700). [PMID:33070277]
4. Wang X et al.. (2020) Susceptibility of Rat Steatotic Liver to Ischemia-Reperfusion Is Treatable With Liver-Selective Matrix Metalloproteinase Inhibition.. Hepatology, 72 (5): (1771-1785). [PMID:32060938]

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