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MMV-390048 - 97%, high purity , CAS No.1314883-11-8

  • Moligand™
  • ≥97%
Item Number
M173331
Grouped product items
SKUSizeAvailabilityPrice Qty
M173331-1mg
1mg
In stock
$39.90
M173331-5mg
5mg
In stock
$162.90
M173331-25mg
25mg
In stock
$543.90
M173331-50mg
50mg
In stock
$870.90
M173331-100mg
100mg
In stock
$1,360.90

Basic Description

Synonyms1314883-11-8|MMV-390048|MMV390048|MMV048|5-(4-(Methylsulfonyl)phenyl)-6'-(trifluoromethyl)-[3,3'-bipyridin]-2-amine|CHEMBL2041980|J3.367.891F|MMV-048|0Z5T00JJ10|5-(4-(Methylsulfonyl)phenyl)-6'-(trifluoromethyl)-3,3'-bipyridine-2-amine|(3,3'-Bipyridin)-2-a
Specifications & PurityMoligand™, ≥97%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Product Description

Product Describtion:

MMV-390048, an antimalarial agent, is an inhibitor of Plasmodium PI4K with Kd of 0.3 μM.

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SCN5A Tclin Sodium channel protein type 5 subunit alpha 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CACNA1C Tclin Voltage-dependent L-type calcium channel subunit alpha-1C 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 5-(4-methylsulfonylphenyl)-3-[6-(trifluoromethyl)pyridin-3-yl]pyridin-2-amine
INCHI InChI=1S/C18H14F3N3O2S/c1-27(25,26)14-5-2-11(3-6-14)13-8-15(17(22)24-10-13)12-4-7-16(23-9-12)18(19,20)21/h2-10H,1H3,(H2,22,24)
InChi Key RTJQABCNNLMCJF-UHFFFAOYSA-N
Canonical SMILES CS(=O)(=O)C1=CC=C(C=C1)C2=CC(=C(N=C2)N)C3=CN=C(C=C3)C(F)(F)F
Isomeric SMILES CS(=O)(=O)C1=CC=C(C=C1)C2=CC(=C(N=C2)N)C3=CN=C(C=C3)C(F)(F)F
PubChem CID 53311393
Molecular Weight 393.383

Certificates

Certificate of Analysis(COA)

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5 results found

Lot NumberCertificate TypeDateItem
C2209178Certificate of AnalysisJan 25, 2022 M173331
C2209593Certificate of AnalysisJan 25, 2022 M173331
C2209594Certificate of AnalysisJan 25, 2022 M173331
C2209597Certificate of AnalysisJan 25, 2022 M173331
C2209598Certificate of AnalysisJan 25, 2022 M173331

Related Documents

References

1. Younis Y, Douelle F, Feng TS, González Cabrera D, Le Manach C, Nchinda AT, Duffy S, White KL, Shackleford DM, Morizzi J et al..  (2012)  3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential..  J Med Chem,  55  (7): (3479-87).  [PMID:22390538]
2. Paquet T, Le Manach C, Cabrera DG, Younis Y, Henrich PP, Abraham TS, Lee MCS, Basak R, Ghidelli-Disse S, Lafuente-Monasterio MJ et al..  (2017)  Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase..  Sci Transl Med,  (387): (589-97).  [PMID:28446690]
3. McCarthy JS, Donini C, Chalon S, Woodford J, Marquart L, Collins KA, Rozenberg FD, Fidock DA, Cherkaoui-Rbati MH, Gobeau N et al..  (2020)  A Phase 1, Placebo-controlled, Randomized, Single Ascending Dose Study and a Volunteer Infection Study to Characterize the Safety, Pharmacokinetics, and Antimalarial Activity of the Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV390048..  Clin Infect Dis,  71  (10): (e657-e664).  [PMID:32239164]
4. McNamara CW, Lee MC, Lim CS, Lim SH, Roland J, Simon O, Yeung BK, Chatterjee AK, McCormack SL, Manary MJ et al..  (2013)  Targeting Plasmodium PI(4)K to eliminate malaria..  Nature,  504  (7479): (248-253).  [PMID:24284631]

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