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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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M126151-5mg | 5mg | In stock | $18.90 | |
M126151-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $77.90 | |
M126151-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $128.90 |
Synonyms | MFCD10565970 | MGCD0103 - Mocetinostat | NCGC00263182-11 | UNII-A6GWB8T96J | DTXSID80222945 | HMS3426I07 | STK387500 | SCHEMBL157027 | AKOS015916602 | MG 0103 | BRD-K16485616-001-04-8 | FT-0627651 | HRNLUBSXIHFDHP-UHFFFAOYSA-N | MOCETINOSTAT [INN] | N-(2- |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | MGCD0103 potently inhibits a subset of the nine human recombinant HDACs, including HDAC1, HDAC2, HDAC3, and HDAC11. MGCD0103 reveals most potent inhibitory activity against human HDAC1 and HDAC2 enzymes in vitro, and it does not inhibit class II HDACs. T |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of histone deacetylase 1;Inhibitor of histone deacetylase 2;Inhibitor of histone deacetylase 3 |
Note | 卖完停产,不再备货 |
Product Description | Mocetinostat (MGCD0103) is a potent HDAC inhibitor with most potency for HDAC1 with IC50 of 0.15 μM, 2- to 10- fold selectivity against HDAC2, 3, and 11, and no activity to HDAC4, 5, 6, 7, and 8. Phase 2. |
ALogP | 2.8 |
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IUPAC Name | N-(2-aminophenyl)-4-[[(4-pyridin-3-ylpyrimidin-2-yl)amino]methyl]benzamide |
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INCHI | InChI=1S/C23H20N6O/c24-19-5-1-2-6-21(19)28-22(30)17-9-7-16(8-10-17)14-27-23-26-13-11-20(29-23)18-4-3-12-25-15-18/h1-13,15H,14,24H2,(H,28,30)(H,26,27,29) |
InChi Key | HRNLUBSXIHFDHP-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC3=NC=CC(=N3)C4=CN=CC=C4 |
Isomeric SMILES | C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC3=NC=CC(=N3)C4=CN=CC=C4 |
PubChem CID | 9865515 |
Molecular Weight | 396.44 |
PubChem CID | 9865515 |
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CAS Registry No. | 726169-73-9 |
ChEMBL Ligand | CHEMBL272980 |
Wikipedia | Mocetinostat |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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H1505067 | Certificate of Analysis | Mar 16, 2023 | M126151 |
Solubility | DMSO 13 mg/mL (32.79 mM); Water <1 mg/mL (<1 mM); Ethanol <1 mg/mL (<1 mM) |
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1. Si-Ke Chen, Da-Wei Pan, Zhuang Liu, Wei Wang, Rui Xie, Xiao-Ting Mu, Xiao-Jie Ju, Liang-Yin Chu. (2023) Microfluidic Fabrication of Calcium Alginate/Chitosan Composite Microcapsules with Ultrathin Shells for Peroxidase Immobilization. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 62 (26): (10101–10111). [PMID:] |
2. Wenfang Song, Hong Lu, Qiansheng Li, Xiaolei Wang, Ze Fu, Jiti Zhou. (2023) Aerobic degradation of ketoprofen by marine consortia: Fenton-like reaction and degradation pathway. SCIENCE OF THE TOTAL ENVIRONMENT, 892 (164520). [PMID:37263434] |
3. Cong Pan, Wenyu Wang, Chenchong Fu, Jong Chol Nam, Feng Wu, Zhixiong You, Jing Xu, Jinjun Li. (2023) Promoted wet peroxide oxidation of chlorinated volatile organic compounds catalyzed by FeOCl supported on macro-microporous biomass-derived activated carbon. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 646 (320). [PMID:37201460] |
4. Junpeng Yue, Hanpei Yang, Chen Liu, Qiang Zhang, Yanhui Ao. (2023) Constructing photocatalysis-self-Fenton system over a defective twin C3N4: In-situ producing H2O2 and mineralizing organic pollutants. APPLIED CATALYSIS B-ENVIRONMENTAL, 331 (122716). [PMID:] |
5. Jianwen Zhou, Tianshang Shan, Hao Luo, Bruno Boury, Xia Xu, Hui Wu, Fengshan Zhang, He Xiao. (2023) Enhanced single-electron transfer for efficiently photocatalytic H2O2 production over g-C3N4 decorated with TEMPO-oxidized cellulosic carbon. Journal of Environmental Chemical Engineering, 11 (109512). [PMID:] |
6. Xin Zhang, Qingling Fu, Hongqing Hu, Jun Zhu, Yonghong Liu. (2023) Effects of Fe(II) on As(III) oxidation in Fe(II)-As(III) co-oxidation: Limiting and driving roles. JOURNAL OF HAZARDOUS MATERIALS, 447 (130790). [PMID:36669406] |
7. Qingli Qu, Weixia Cheng, Xiaoli Zhang, Hossein Ravanbakhsh, Guosheng Tang, Aying Zhou, Dong Pei, Ranhua Xiong, Chaobo Huang. (2022) Glucose-Responsive Enzymatic Cascade Microreactors in Gas-Shearing Microfluidics Microcapsules. Advanced Materials Technologies, 8 (5): (2201559). [PMID:] |
8. Chenchong Fu, Cong Pan, Tao Chen, Deqin Peng, Yaqian Liu, Feng Wu, Jing Xu, Zhixiong You, Jinjun Li, Liting Luo. (2022) Adsorption-enforced Fenton-like process using activated carbon-supported iron oxychloride catalyst for wet scrubbing of airborne dichloroethane. CHEMOSPHERE, 307 (136193). [PMID:36037963] |
9. Qingli Qu, Weixia Cheng, Xiaoli Zhang, Aying Zhou, Yankang Deng, Miaomiao Zhu, Tianjiao Chu, Bella B. Manshian, Ranhua Xiong, Stefaan J. Soenen, Kevin Braeckmans, Stefaan C. De Smedt, Chaobo Huang. (2022) Multicompartmental Microcapsules for Enzymatic Cascade Reactions Prepared through Gas Shearing and Surface Gelation. BIOMACROMOLECULES, 23 (9): (3572–3581). [PMID:35931466] |
10. Cailiang Yue, Changqing Zhu, Wenting Zheng, Jinli Qiu, Zhiling Du, Chen Ling, Fu-Qiang Liu. (2022) Plasmonic Bi NP-accelerated interfacial charge transfer for enhanced solar-driven ciprofloxacin mineralization. Environmental Science-Nano, 9 (1): (349-360). [PMID:] |
11. Shuangqin Li, Di Liu, Bingyan Wu, Huipeng Sun, Xiaoyan Liu, Haixia Zhang, Nana Ding, Lan Wu. (2022) One-pot synthesis of a peroxidase-like nanozyme and its application in visual assay for tyrosinase activity. TALANTA, 239 (123088). [PMID:34838324] |
12. Teng Ge, Xiaoli Jin, Jian Cao, Zhuohua Chen, Yixue Xu, Haiquan Xie, Fengyun Su, Xin Li, Qing Lan, Liqun Ye. (2021) Giant enhanced photocatalytic H2O2 production over hollow hexagonal prisms carbon nitride. Journal of the Taiwan Institute of Chemical Engineers, 129 (104). [PMID:] |
13. Qingli Qu, Xiaoli Zhang, Hossein Ravanbakhsh, Guosheng Tang, Jian Zhang, Yankang Deng, Kevin Braeckmans, Stefaan C. De Smedt, Ranhua Xiong, Chaobo Huang. (2022) Gas-shearing synthesis of core–shell multicompartmental microparticles as cell-like system for enzymatic cascade reaction. CHEMICAL ENGINEERING JOURNAL, 428 (132607). [PMID:] |
14. Yuqing Wu, Lei Cao, Minghui Zan, Zheng Hou, Mingfeng Ge, Wen-Fei Dong, Li Li. (2021) Iron and nitrogen-co-doped carbon quantum dots for the sensitive and selective detection of hematin and ferric ions and cell imaging. ANALYST, 146 (15): (4954-4963). [PMID:34259240] |
15. Fangfang Zhou, Jianquan Luo, Siqing Song, Yinhua Wan. (2020) Nanostructured Polyphenol-Mediated Coating: a Versatile Platform for Enzyme Immobilization and Micropollutant Removal. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 59 (7): (2708–2717). [PMID:] |
16. Lili Wang, Wencheng Gong, Fang Wang, Zhenya Yu, Zilin Chen. (2016) Efficient bienzyme nanocomposite film for chiral recognition of L-tryptophan, L-phenylalanine and L-tyrosine. Analytical Methods, 8 (17): (3481-3487). [PMID:] |
17. Wang Fang, Gong Wencheng, Wang Lili, Chen Zilin. (2015) Enhanced amperometric response of a glucose oxidase and horseradish peroxidase based bienzyme glucose biosensor modified with a film of polymerized toluidine blue containing reduced graphene oxide. MICROCHIMICA ACTA, 182 (11): (1949-1956). [PMID:] |
18. Wei Ding,Jing Xu,Tao Chen,Chengshuai Liu,Jinjun Li,Feng Wu. (2018-07-20) Co-oxidation of As(III) and Fe(II) by oxygen through complexation between As(III) and Fe(II)/Fe(III) species.. Water research, 143 (599-607). [PMID:30025352] |
1. Bradner JE, West N, Grachan ML, Greenberg EF, Haggarty SJ, Warnow T, Mazitschek R. (2010) Chemical phylogenetics of histone deacetylases.. Nat Chem Biol, 6 (3): (238-243). [PMID:20139990] |
2. Si-Ke Chen, Da-Wei Pan, Zhuang Liu, Wei Wang, Rui Xie, Xiao-Ting Mu, Xiao-Jie Ju, Liang-Yin Chu. (2023) Microfluidic Fabrication of Calcium Alginate/Chitosan Composite Microcapsules with Ultrathin Shells for Peroxidase Immobilization. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 62 (26): (10101–10111). [PMID:] |
3. Wenfang Song, Hong Lu, Qiansheng Li, Xiaolei Wang, Ze Fu, Jiti Zhou. (2023) Aerobic degradation of ketoprofen by marine consortia: Fenton-like reaction and degradation pathway. SCIENCE OF THE TOTAL ENVIRONMENT, 892 (164520). [PMID:37263434] |
4. Cong Pan, Wenyu Wang, Chenchong Fu, Jong Chol Nam, Feng Wu, Zhixiong You, Jing Xu, Jinjun Li. (2023) Promoted wet peroxide oxidation of chlorinated volatile organic compounds catalyzed by FeOCl supported on macro-microporous biomass-derived activated carbon. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 646 (320). [PMID:37201460] |
5. Junpeng Yue, Hanpei Yang, Chen Liu, Qiang Zhang, Yanhui Ao. (2023) Constructing photocatalysis-self-Fenton system over a defective twin C3N4: In-situ producing H2O2 and mineralizing organic pollutants. APPLIED CATALYSIS B-ENVIRONMENTAL, 331 (122716). [PMID:] |
6. Jianwen Zhou, Tianshang Shan, Hao Luo, Bruno Boury, Xia Xu, Hui Wu, Fengshan Zhang, He Xiao. (2023) Enhanced single-electron transfer for efficiently photocatalytic H2O2 production over g-C3N4 decorated with TEMPO-oxidized cellulosic carbon. Journal of Environmental Chemical Engineering, 11 (109512). [PMID:] |
7. Xin Zhang, Qingling Fu, Hongqing Hu, Jun Zhu, Yonghong Liu. (2023) Effects of Fe(II) on As(III) oxidation in Fe(II)-As(III) co-oxidation: Limiting and driving roles. JOURNAL OF HAZARDOUS MATERIALS, 447 (130790). [PMID:36669406] |
8. Qingli Qu, Weixia Cheng, Xiaoli Zhang, Hossein Ravanbakhsh, Guosheng Tang, Aying Zhou, Dong Pei, Ranhua Xiong, Chaobo Huang. (2022) Glucose-Responsive Enzymatic Cascade Microreactors in Gas-Shearing Microfluidics Microcapsules. Advanced Materials Technologies, 8 (5): (2201559). [PMID:] |
9. Chenchong Fu, Cong Pan, Tao Chen, Deqin Peng, Yaqian Liu, Feng Wu, Jing Xu, Zhixiong You, Jinjun Li, Liting Luo. (2022) Adsorption-enforced Fenton-like process using activated carbon-supported iron oxychloride catalyst for wet scrubbing of airborne dichloroethane. CHEMOSPHERE, 307 (136193). [PMID:36037963] |
10. Qingli Qu, Weixia Cheng, Xiaoli Zhang, Aying Zhou, Yankang Deng, Miaomiao Zhu, Tianjiao Chu, Bella B. Manshian, Ranhua Xiong, Stefaan J. Soenen, Kevin Braeckmans, Stefaan C. De Smedt, Chaobo Huang. (2022) Multicompartmental Microcapsules for Enzymatic Cascade Reactions Prepared through Gas Shearing and Surface Gelation. BIOMACROMOLECULES, 23 (9): (3572–3581). [PMID:35931466] |
11. Cailiang Yue, Changqing Zhu, Wenting Zheng, Jinli Qiu, Zhiling Du, Chen Ling, Fu-Qiang Liu. (2022) Plasmonic Bi NP-accelerated interfacial charge transfer for enhanced solar-driven ciprofloxacin mineralization. Environmental Science-Nano, 9 (1): (349-360). [PMID:] |
12. Shuangqin Li, Di Liu, Bingyan Wu, Huipeng Sun, Xiaoyan Liu, Haixia Zhang, Nana Ding, Lan Wu. (2022) One-pot synthesis of a peroxidase-like nanozyme and its application in visual assay for tyrosinase activity. TALANTA, 239 (123088). [PMID:34838324] |
13. Teng Ge, Xiaoli Jin, Jian Cao, Zhuohua Chen, Yixue Xu, Haiquan Xie, Fengyun Su, Xin Li, Qing Lan, Liqun Ye. (2021) Giant enhanced photocatalytic H2O2 production over hollow hexagonal prisms carbon nitride. Journal of the Taiwan Institute of Chemical Engineers, 129 (104). [PMID:] |
14. Qingli Qu, Xiaoli Zhang, Hossein Ravanbakhsh, Guosheng Tang, Jian Zhang, Yankang Deng, Kevin Braeckmans, Stefaan C. De Smedt, Ranhua Xiong, Chaobo Huang. (2022) Gas-shearing synthesis of core–shell multicompartmental microparticles as cell-like system for enzymatic cascade reaction. CHEMICAL ENGINEERING JOURNAL, 428 (132607). [PMID:] |
15. Yuqing Wu, Lei Cao, Minghui Zan, Zheng Hou, Mingfeng Ge, Wen-Fei Dong, Li Li. (2021) Iron and nitrogen-co-doped carbon quantum dots for the sensitive and selective detection of hematin and ferric ions and cell imaging. ANALYST, 146 (15): (4954-4963). [PMID:34259240] |
16. Fangfang Zhou, Jianquan Luo, Siqing Song, Yinhua Wan. (2020) Nanostructured Polyphenol-Mediated Coating: a Versatile Platform for Enzyme Immobilization and Micropollutant Removal. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 59 (7): (2708–2717). [PMID:] |
17. Lili Wang, Wencheng Gong, Fang Wang, Zhenya Yu, Zilin Chen. (2016) Efficient bienzyme nanocomposite film for chiral recognition of L-tryptophan, L-phenylalanine and L-tyrosine. Analytical Methods, 8 (17): (3481-3487). [PMID:] |
18. Wang Fang, Gong Wencheng, Wang Lili, Chen Zilin. (2015) Enhanced amperometric response of a glucose oxidase and horseradish peroxidase based bienzyme glucose biosensor modified with a film of polymerized toluidine blue containing reduced graphene oxide. MICROCHIMICA ACTA, 182 (11): (1949-1956). [PMID:] |
19. Wei Ding,Jing Xu,Tao Chen,Chengshuai Liu,Jinjun Li,Feng Wu. (2018-07-20) Co-oxidation of As(III) and Fe(II) by oxygen through complexation between As(III) and Fe(II)/Fe(III) species.. Water research, 143 (599-607). [PMID:30025352] |