Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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M118359-10mg | 10mg | In stock | $48.90 | |
M118359-50mg | 50mg | In stock | $137.90 | |
M118359-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $206.90 | |
M118359-250mg | 250mg | In stock | $465.90 |
Reversible, non-competitive, slow-binding MAO-A inhibitor
Synonyms | BCP15783 | Ro111163 | Ro-11-1163 | DTXSID9040554 | MOCLOBEMIDE [MI] | MOCLOBEMIDE [INN] | Ro-11-1163/000 | BENZAMIDE,4-CHLORO-N-[2-(4-MORPHOLINYL)ETHYL]- | SR-01000357772-4 | 4-Chloro-N-[2-(4-morpholinyl)ethyl] benzamide | AC-35244 | MLS001424077 | NC0012 |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Moclobemide is a reversible and selective inhibitor of monoamine oxidase A (MAO-A).Reversible, non-competitive slow-binding MAO-A inhibitor (IC 50 = 500 μM). Shows antidepressant, anxiolytic, neuroprotective and anti-ischemic effects in vivo. Orally activ |
Storage Temp | Room temperature |
Shipped In | Normal |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Monoamine oxidase A inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Moclobemide is a MAO-A (5-HT) inhibitor with IC50 of 6.1 μM. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 4-chloro-N-(2-morpholin-4-ylethyl)benzamide |
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INCHI | InChI=1S/C13H17ClN2O2/c14-12-3-1-11(2-4-12)13(17)15-5-6-16-7-9-18-10-8-16/h1-4H,5-10H2,(H,15,17) |
InChi Key | YHXISWVBGDMDLQ-UHFFFAOYSA-N |
Canonical SMILES | C1COCCN1CCNC(=O)C2=CC=C(C=C2)Cl |
Isomeric SMILES | C1COCCN1CCNC(=O)C2=CC=C(C=C2)Cl |
WGK Germany | 2 |
RTECS | CV2462000 |
PubChem CID | 4235 |
Molecular Weight | 268.74 |
Reaxy-Rn | 530974 |
ChEMBL Ligand | CHEMBL86304 |
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Wikipedia | Moclobemide |
PubChem CID | 4235 |
CAS Registry No. | 71320-77-9 |
DrugBank Ligand | DB01171 |
PEP | moclobemide |
DrugCentral Ligand | 1825 |
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Solubility | Soluble in isopropanol, methanol, DMSO (>20 mg/ml), ethanol (100 mM), and water (partly miscible). |
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Melt Point(°C) | 138 °C |
Pictogram(s) | GHS05, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H335:May cause respiratory irritation H302:Harmful if swallowed H318:Causes serious eye damage |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 2 |
RTECS | CV2462000 |
Reaxy-Rn | 530974 |
Merck Index | 6226 |
1. Fulton B, Benfield P. (1996) Moclobemide. An update of its pharmacological properties and therapeutic use.. Drugs, 52 (3): (450-74). [PMID:8875133] [10.1021/op500134e] |