mofegiline , CAS No.119386-96-8, Inhibitor of amine oxidase copper containing 3;Inhibitor of Monoamine oxidase B

Item Number
M611981
Grouped product items
SKUSizeAvailabilityPrice Qty
M611981-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,300.90
M611981-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90

Basic Description

Synonyms(e)-2-(4-fluorophenethyl)-3-fluoroallylamine | Mofegiline [INN] | BDBM50246766 | MDL-72,974 | SCHEMBL1295041 | (2E)-2-(fluoromethylidene)-4-(4-fluorophenyl)butan-1-amine | (E)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane | 1FMJ6D8Y1B | Benzenebuta
Specifications & PurityMoligand™
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of amine oxidase copper containing 3;Inhibitor of Monoamine oxidase B

Associated Targets(Human)

AOC3 Tchem Membrane primary amine oxidase (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MAOB Tclin Amine oxidase [flavin-containing] B (4 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOB Tclin Monoamine oxidase B (8835 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AOC1 Tchem Diamine oxidase (68 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AOC2 Tchem Retina-specific amine oxidase, copper containing (42 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DAO Tchem D-amino-acid oxidase (802 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AOC3 Amine oxidase, copper containing (44 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (2E)-2-(fluoromethylidene)-4-(4-fluorophenyl)butan-1-amine
INCHI InChI=1S/C11H13F2N/c12-7-10(8-14)2-1-9-3-5-11(13)6-4-9/h3-7H,1-2,8,14H2/b10-7+
InChi Key VXLBSYHAEKDUSU-JXMROGBWSA-N
Canonical SMILES C1=CC(=CC=C1CCC(=CF)CN)F
Isomeric SMILES C1=CC(=CC=C1CC/C(=C\F)/CN)F
Alternate CAS 119386-96-8
PubChem CID 6437850
MeSH Entry Terms 4-fluoro-beta-(fluoromethylene)benzenebutanamine;MDL 72974;MDL-72,974;MDL-72974A;mofegiline

Certificates

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Related Documents

References

1. Yu PH, Zuo DM.  (1992)  Inhibition of a type B monoamine oxidase inhibitor, (E)-2-(4-fluorophenethyl)-3-fluoroallylamine (MDL-72974A), on semicarbazide-sensitive amine oxidases isolated from vascular tissues and sera of different species..  Biochem Pharmacol,  43  (2): (307-12).  [PMID:1739419] [10.1021/op500134e]
2. Terleckyj IA, Heikkila RE.  (1992)  In vivo and in vitro pharmacologic profile of two new irreversible MAO-B inhibitors: MDL 72,974A and fluorodeprenyl..  Ann N Y Acad Sci,  648  (13): (365-7).  [PMID:1637071] [10.1021/op500134e]
3. Foot JS, Yow TT, Schilter H, Buson A, Deodhar M, Findlay AD, Guo L, McDonald IA, Turner CI, Zhou W et al..  (2013)  PXS-4681A, a potent and selective mechanism-based inhibitor of SSAO/VAP-1 with anti-inflammatory effects in vivo..  J Pharmacol Exp Ther,  347  (2): (365-74).  [PMID:23943052] [10.1021/op500134e]
4. Stoltz M, Reynolds D, Elkins L, Salazar D, Weir S.  (1995)  Pharmacokinetics and pharmacodynamics of the monoamine oxidase B inhibitor mofegiline assessed during a phase I dose tolerance trial..  Clin Pharmacol Ther,  58  (3): (342-53).  [PMID:7554709] [10.1021/op500134e]

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