Molidustat (BAY 85-3934) - 98%, high purity , Egl nine homolog 3 inhibitor, CAS No.1154028-82-6, Egl nine homolog 3 inhibitor

Item Number

M413917

• Synonyms: 3H-Pyrazol-3-one, 1,2-dihydro-2-[6-(4-morpholinyl)-4-pyrimidinyl]-4-(1H-1,2,3-triazol-1-yl)- | Molidustat(BAY 85-3934) | NCGC00388364-04 | UNII-9JH486CZ13 | 2-(6-Morpholin-4-Ylpyrimidin-4-Yl)-4-(1,2,3-Triazol-1-Yl)-1~{h}-Pyrazol-3-One | BCP14477 | DTXSID8
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: Molidustat (BAY 85-3934) is a potent hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor with IC50 of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD, respectively. Phase 2.
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Egl nine homolog 3 inhibitor

Product Description

Information

Molidustat (BAY 85-3934) Molidustat (BAY 85-3934) is a potent hypoxia-inducible factor prolyl hydroxylase ( HIF-PH ) inhibitor with IC50 of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD, respectively. Phase 2.

Targets

PHD2 (Cell-free assay); PHD3 (Cell-free assay); PHD1 (Cell-free assay) 280 nM; 450 nM; 480 nM

In vitro

Molidustat induces the transcription of hypoxia-sensitive genes in HeLa, A549, and Hep3B cells.

In vivo

In healthy Wistar rats and cynomolgus monkeys, Molidustat (1.5 mg/kg, p.o.) induces dose-dependent production of EPO and erythropoiesis. In rats with gentamicin-induced renal anemiabe, Molidustat (5 mg/kg, p.o.) is also effective in raising hematocrit levels while stimulating endogenous EPO production without hypertensive effects.