Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
M114127-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $68.90 | |
M114127-500mg | 500mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $240.90 |
Synonyms | CAS-4376-20-9 | rac Mono(ethylhexyl) Phthalate-d4 | 1,2-Benzenedicarboxylic Acid Mono(2-ethylhexyl) Ester | 2-[(2S)-2-ethylhexoxy]carbonylbenzoic acid | FT-0600523 | Phthalic acid hydrogen 1-(2-ethylhexyl) ester | BRD-A18246003-001-01-1 | Monoethylhexyl p |
---|---|
Specifications & Purity | analytical standard |
Biochemical and Physiological Mechanisms | MEHP is a bioactive metabolite of DEHP which inhibits the 17,20 lyase activity of CYP17. MEHP has been shown to modulate the expression of a broad spectrum of genes, including the downregulation of the steroidogenic genes Insl3, expressed in Leydig cells, |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | analytical standard |
Note | 250mg售完停产,不再备货 |
Product Description | A bioactive metabolite of DEHP. |
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
---|
IUPAC Name | 2-(2-ethylhexoxycarbonyl)benzoic acid |
---|---|
INCHI | InChI=1S/C16H22O4/c1-3-5-8-12(4-2)11-20-16(19)14-10-7-6-9-13(14)15(17)18/h6-7,9-10,12H,3-5,8,11H2,1-2H3,(H,17,18) |
InChi Key | DJDSLBVSSOQSLW-UHFFFAOYSA-N |
Canonical SMILES | CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)O |
Isomeric SMILES | CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)O |
PubChem CID | 20393 |
Molecular Weight | 278.34 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
K2208295 | Certificate of Analysis | Aug 23, 2024 | M114127 |
J2326474 | Certificate of Analysis | Oct 08, 2023 | M114127 |
J2326496 | Certificate of Analysis | Oct 08, 2023 | M114127 |
K2117360 | Certificate of Analysis | Aug 09, 2023 | M114127 |
K2117376 | Certificate of Analysis | Aug 09, 2023 | M114127 |
E2129239 | Certificate of Analysis | Mar 10, 2023 | M114127 |
K2208296 | Certificate of Analysis | Sep 12, 2022 | M114127 |
Refractive Index | 1.5051 |
---|
1. Bo Xu, Tiantian He, Hong Yang, Wenjie Dai, Ling Liu, Xiaoqian Ma, Jiaxue Ma, Guoqin Yang, Rui Si, Xing Du, Xufeng Fu, Xiuying Pei. (2023) Activation of the p62-Keap1-Nrf2 pathway protects against oxidative stress and excessive autophagy in ovarian granulosa cells to attenuate DEHP-induced ovarian impairment in mice. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 265 (115534). [PMID:37776821] [10.1016/j.ecoenv.2023.115534] |
2. Yifan Hong, Xiazhu Zhou, Qi Li, Jing Chen, Yuexin Wei, Siyuan Wang, Xiangqin Zheng, Jie Zhao, Chengjun Yu, Jun Pei, Jie Zhang, Chunlan Long, Lianju Shen, Shengde Wu, Guanghui Wei. (2023) Wnt10a downregulation contributes to MEHP-induced disruption of self-renewal and differentiation balance and proliferation inhibition in GC-1 cells: Insights from multiple transcriptomic profiling. ENVIRONMENTAL POLLUTION, 333 (122091). [PMID:37364752] [10.1016/j.envpol.2023.122091] |
3. Fan Zhang, Hualong Zhen, Hengshun Cheng, Fengying Hu, Yunfei Jia, Binbin Huang, Minmin Jiang. (2022) Di-(2-ethylhexyl) phthalate exposure induces liver injury by promoting ferroptosis via downregulation of GPX4 in pregnant mice. Frontiers in Cell and Developmental Biology, 10 (1014243). [PMID:36438553] [10.3389/fcell.2022.1014243] |
4. Fang Guo, Yaoyin Lou, Qun Yan, Jianglei Xiong, Jiahao Luo, Chikang Shen, Dimitris V. Vayenas. (2023) Insight into the Fe–Ni/biochar composite supported three-dimensional electro-Fenton removal of electronic industry wastewater. JOURNAL OF ENVIRONMENTAL MANAGEMENT, 325 (116466). [PMID:36327605] [10.1016/j.jenvman.2022.116466] |
5. Xiaofang Zhu, Haowei Fu, Jiahui Sun, Qiannan Di, Qian Xu. (2022) N6-methyladenosine modification on Hmbox1 is related to telomere dysfunction in DEHP-induced male reproductive injury. LIFE SCIENCES, 309 (121005). [PMID:36174712] [10.1016/j.lfs.2022.121005] |
6. Yiwei Fang, Zhiliang Chen, Jinyu Chen, Minqi Zhou, Yuanyao Chen, Rong Cao, Chunyan Liu, Kai Zhao, Min Wang, Huiping Zhang. (2023) Dose–response mapping of MEHP exposure with metabolic changes of trophoblast cell and determination of sensitive markers. SCIENCE OF THE TOTAL ENVIRONMENT, 855 (158924). [PMID:36152845] [10.1016/j.scitotenv.2022.158924] |
7. Jianqiang Sun, Haofeng Zhu, Xindong Yang, Yan Zheng, Tianchi Sun, Honglei Xu, Jiaqi Meng, Anping Zhang. (2022) Carboxylesterase and lipase-catalyzed degradation of phthalate esters in soil and water: Congener structure selectivity and specificity. Environmental Technology & Innovation, 28 (102571). [PMID:] [10.1016/j.eti.2022.102571] |
8. Yue Leng, Li Ren, Shu Niu, Tiehua Zhang, Jie Zhang. (2021) In vitro and in silico investigations of endocrine disruption induced by metabolites of plasticizers through glucocorticoid receptor. FOOD AND CHEMICAL TOXICOLOGY, 155 (112413). [PMID:34273429] [10.1016/j.fct.2021.112413] |
9. Jianying Bai, Zhen He, Yaofu Li, Xuexia Jiang, Hongmei Yu, Qing Tan. (2019) Mono-2-ethylhexyl phthalate induces the expression of genes involved in fatty acid synthesis in HepG2 cells. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 69 (104). [PMID:31004931] [10.1016/j.etap.2019.04.004] |
10. Hai-Ming Zhao, Rui-Wen Hu, Xue-Xue Chen, Xue-Bin Chen, Huixiong Lü, Yan-Wen Li, Hui Li, Ce-Hui Mo, Quan-Ying Cai, Ming-Hung Wong. (2018) Biodegradation pathway of di-(2-ethylhexyl) phthalate by a novel Rhodococcus pyridinivorans XB and its bioaugmentation for remediation of DEHP contaminated soil. SCIENCE OF THE TOTAL ENVIRONMENT, 640-641 (1121). [PMID:30021277] [10.1016/j.scitotenv.2018.05.334] |
11. Zhao Hai-Ming, Hu Rui-Wen, Huang He-Biao, Wen Hong-Fei, Du Huan, Li Yan-Wen, Li Hui, Cai Quan-Ying, Mo Ce-Hui, Liu Jie-Sheng, Wong Ming-Hung. (2017) Enhanced dissipation of DEHP in soil and simultaneously reduced bioaccumulation of DEHP in vegetable using bioaugmentation with exogenous bacteria. BIOLOGY AND FERTILITY OF SOILS, 53 (6): (663-675). [PMID:] [10.1007/s00374-017-1208-y] |
12. Hai-Ming Zhao, Huan Du, Jing Lin, Xue-Bin Chen, Yan-Wen Li, Hui Li, Quan-Ying Cai, Ce-Hui Mo, Hua-Ming Qin, Ming-Hung Wong. (2016) Complete degradation of the endocrine disruptor di-(2-ethylhexyl) phthalate by a novel Agromyces sp. MT-O strain and its application to bioremediation of contaminated soil. SCIENCE OF THE TOTAL ENVIRONMENT, 562 (170). [PMID:27099998] [10.1016/j.scitotenv.2016.03.171] |
13. Jiarong Qiu,Yueqi Zhang,Yaning Shi,Junwei Jiang,Shenglu Wu,Longxiang Li,Yuting Shao,Zhihong Xin. (2020-01-09) Identification and characterization of a novel phthalate-degrading hydrolase from a soil metagenomic library.. Ecotoxicology and environmental safety, 190 (110148-110148). [PMID:31911388] |
1. Bo Xu, Tiantian He, Hong Yang, Wenjie Dai, Ling Liu, Xiaoqian Ma, Jiaxue Ma, Guoqin Yang, Rui Si, Xing Du, Xufeng Fu, Xiuying Pei. (2023) Activation of the p62-Keap1-Nrf2 pathway protects against oxidative stress and excessive autophagy in ovarian granulosa cells to attenuate DEHP-induced ovarian impairment in mice. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 265 (115534). [PMID:37776821] [10.1016/j.ecoenv.2023.115534] |
2. Yifan Hong, Xiazhu Zhou, Qi Li, Jing Chen, Yuexin Wei, Siyuan Wang, Xiangqin Zheng, Jie Zhao, Chengjun Yu, Jun Pei, Jie Zhang, Chunlan Long, Lianju Shen, Shengde Wu, Guanghui Wei. (2023) Wnt10a downregulation contributes to MEHP-induced disruption of self-renewal and differentiation balance and proliferation inhibition in GC-1 cells: Insights from multiple transcriptomic profiling. ENVIRONMENTAL POLLUTION, 333 (122091). [PMID:37364752] [10.1016/j.envpol.2023.122091] |
3. Fan Zhang, Hualong Zhen, Hengshun Cheng, Fengying Hu, Yunfei Jia, Binbin Huang, Minmin Jiang. (2022) Di-(2-ethylhexyl) phthalate exposure induces liver injury by promoting ferroptosis via downregulation of GPX4 in pregnant mice. Frontiers in Cell and Developmental Biology, 10 (1014243). [PMID:36438553] [10.3389/fcell.2022.1014243] |
4. Fang Guo, Yaoyin Lou, Qun Yan, Jianglei Xiong, Jiahao Luo, Chikang Shen, Dimitris V. Vayenas. (2023) Insight into the Fe–Ni/biochar composite supported three-dimensional electro-Fenton removal of electronic industry wastewater. JOURNAL OF ENVIRONMENTAL MANAGEMENT, 325 (116466). [PMID:36327605] [10.1016/j.jenvman.2022.116466] |
5. Xiaofang Zhu, Haowei Fu, Jiahui Sun, Qiannan Di, Qian Xu. (2022) N6-methyladenosine modification on Hmbox1 is related to telomere dysfunction in DEHP-induced male reproductive injury. LIFE SCIENCES, 309 (121005). [PMID:36174712] [10.1016/j.lfs.2022.121005] |
6. Yiwei Fang, Zhiliang Chen, Jinyu Chen, Minqi Zhou, Yuanyao Chen, Rong Cao, Chunyan Liu, Kai Zhao, Min Wang, Huiping Zhang. (2023) Dose–response mapping of MEHP exposure with metabolic changes of trophoblast cell and determination of sensitive markers. SCIENCE OF THE TOTAL ENVIRONMENT, 855 (158924). [PMID:36152845] [10.1016/j.scitotenv.2022.158924] |
7. Jianqiang Sun, Haofeng Zhu, Xindong Yang, Yan Zheng, Tianchi Sun, Honglei Xu, Jiaqi Meng, Anping Zhang. (2022) Carboxylesterase and lipase-catalyzed degradation of phthalate esters in soil and water: Congener structure selectivity and specificity. Environmental Technology & Innovation, 28 (102571). [PMID:] [10.1016/j.eti.2022.102571] |
8. Yue Leng, Li Ren, Shu Niu, Tiehua Zhang, Jie Zhang. (2021) In vitro and in silico investigations of endocrine disruption induced by metabolites of plasticizers through glucocorticoid receptor. FOOD AND CHEMICAL TOXICOLOGY, 155 (112413). [PMID:34273429] [10.1016/j.fct.2021.112413] |
9. Jianying Bai, Zhen He, Yaofu Li, Xuexia Jiang, Hongmei Yu, Qing Tan. (2019) Mono-2-ethylhexyl phthalate induces the expression of genes involved in fatty acid synthesis in HepG2 cells. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 69 (104). [PMID:31004931] [10.1016/j.etap.2019.04.004] |
10. Hai-Ming Zhao, Rui-Wen Hu, Xue-Xue Chen, Xue-Bin Chen, Huixiong Lü, Yan-Wen Li, Hui Li, Ce-Hui Mo, Quan-Ying Cai, Ming-Hung Wong. (2018) Biodegradation pathway of di-(2-ethylhexyl) phthalate by a novel Rhodococcus pyridinivorans XB and its bioaugmentation for remediation of DEHP contaminated soil. SCIENCE OF THE TOTAL ENVIRONMENT, 640-641 (1121). [PMID:30021277] [10.1016/j.scitotenv.2018.05.334] |
11. Zhao Hai-Ming, Hu Rui-Wen, Huang He-Biao, Wen Hong-Fei, Du Huan, Li Yan-Wen, Li Hui, Cai Quan-Ying, Mo Ce-Hui, Liu Jie-Sheng, Wong Ming-Hung. (2017) Enhanced dissipation of DEHP in soil and simultaneously reduced bioaccumulation of DEHP in vegetable using bioaugmentation with exogenous bacteria. BIOLOGY AND FERTILITY OF SOILS, 53 (6): (663-675). [PMID:] [10.1007/s00374-017-1208-y] |
12. Hai-Ming Zhao, Huan Du, Jing Lin, Xue-Bin Chen, Yan-Wen Li, Hui Li, Quan-Ying Cai, Ce-Hui Mo, Hua-Ming Qin, Ming-Hung Wong. (2016) Complete degradation of the endocrine disruptor di-(2-ethylhexyl) phthalate by a novel Agromyces sp. MT-O strain and its application to bioremediation of contaminated soil. SCIENCE OF THE TOTAL ENVIRONMENT, 562 (170). [PMID:27099998] [10.1016/j.scitotenv.2016.03.171] |
13. Jiarong Qiu,Yueqi Zhang,Yaning Shi,Junwei Jiang,Shenglu Wu,Longxiang Li,Yuting Shao,Zhihong Xin. (2020-01-09) Identification and characterization of a novel phthalate-degrading hydrolase from a soil metagenomic library.. Ecotoxicology and environmental safety, 190 (110148-110148). [PMID:31911388] |