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Hydroxycarboxylic acid receptors
Monomethyl Fumarate - >98.0%(GC), high purity , CAS No.2756-87-8, Agonist of HCA 2 receptor

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Monomethyl Fumarate - >98.0%(GC), high purity , CAS No.2756-87-8, Agonist of HCA 2 receptor

Moligand™

≥98%(GC)

CAS#: 2756-87-8
Formula: C₅H₆O₄
Molecular Weight: 130.1
MDL number: MFCD00063174
PubChem CID: 5369209
PubChem SID: 488195478

Item Number

M158861

Grouped product items
SKU	Size	Availability	Price
M158861-1g	1g	In stock	$9.90
M158861-5g	5g	In stock	$31.90
M158861-10g	10g	In stock	$56.90
M158861-25g	25g	In stock	$144.90
M158861-100g	100g	In stock	$519.90

Activator of Nrf2 pathway; primary metabolite ofDMF(Cat. No. 4512)

View related series

Drug Metabolite GPCR/G Protein GPR109A HCA2 receptor Agonist Metabolic Enzyme/Protease

Basic Description

Synonyms	Maleicacidmonomethylester \| Sun mark sinus \| FUMARIC ACID MONOMETHYL ESTER [MI] \| M2413 \| Methyl hydrogen fumarate \| (E)-2-Butendioic acid, methyl ester \| (E)-4-methoxy-4-oxobut-2-enoic acid \| CHEBI:167450 \| (E)-4-methoxy-4-oxobut-2-enoicacid \| 4,4'-Diflo
Specifications & Purity	Moligand™, ≥98%(GC)
Biochemical and Physiological Mechanisms	Nuclear factor (erythroid-derived-2)-like 2 (Nrf2) pathway activator. Also exhibits agonist activity at GPR109A. Primary metabolite ofDMF.
Storage Temp	Argon charged
Shipped In	Normal
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of HCA 2 receptor
Product Description	mono-Methyl fumarate can be used as a reactant to synthesize: · Jumonji C domain-containing histone demethylases (JCHDMs) inhibitor. · (-)-Xylariamide A, a fungal metabolite. · (±)-Methoxyfumimycin ethyl ester, a potential bacterial peptide deformylase inhibitor. It is also a wide spectrum antibacterial agent with a powerful antioxidant activity.

Product Properties

ALogP	0.4

Associated Targets(Human)

HCAR2 Tclin Hydroxycarboxylic acid receptor 2 (2 Activities)

Discover Target: HCAR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CA2 Tclin Carbonic anhydrase II (17698 Activities)

Discover Target: CA2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CA1 Tclin Carbonic anhydrase I (13240 Activities)

Discover Target: CA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CA5B Tclin Carbonic anhydrase VB (957 Activities)

Discover Target: CA5B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CA5A Tclin Carbonic anhydrase VA (1168 Activities)

Discover Target: CA5A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hcar2 Hydroxycarboxylic acid receptor 2 (55 Activities)

Discover Target: Hcar2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RAW264.7 (28094 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

Discover Target: Nfe2l2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488195478
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488195478
IUPAC Name	(E)-4-methoxy-4-oxobut-2-enoic acid
INCHI	InChI=1S/C5H6O4/c1-9-5(8)3-2-4(6)7/h2-3H,1H3,(H,6,7)/b3-2+
InChi Key	NKHAVTQWNUWKEO-NSCUHMNNSA-N
Canonical SMILES	COC(=O)C=CC(=O)O
Isomeric SMILES	COC(=O)/C=C/C(=O)O
WGK Germany	3
PubChem CID	5369209
Molecular Weight	130.1

Database links

CAS Registry No.	2756-87-8
PubChem CID	5369209
ChEMBL Ligand	CHEMBL589586
PEP	monomethylfumarate
GPCRdb Ligand	monomethyl fumarate
PubChem SID	488195478

Certificates

Certificate of Analysis(COA)

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6 results found

Lot Number	Certificate Type	Date	Item
D2320331	Certificate of Analysis	Oct 28, 2022	M158861
K2215282	Certificate of Analysis	Oct 28, 2022	M158861
K2215309	Certificate of Analysis	Oct 28, 2022	M158861
K2215316	Certificate of Analysis	Oct 28, 2022	M158861
K2215318	Certificate of Analysis	Oct 28, 2022	M158861
K2215349	Certificate of Analysis	Oct 28, 2022	M158861

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 13.01, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 13.01, Max Conc. mM: 100
Melt Point(°C)	145-149°C

Safety and Hazards(GHS)

Pictogram(s)	GHS05
Signal	Danger
Hazard Statements	H318:Causes serious eye damage
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help.
WGK Germany	3

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