Mosunetuzumab (anti-CD20&CD3e) - Primary antibody, specific to MS4A1 & CD3E, Human IgG1, Antibody of CD20 (membrane-spanning 4-domains; subfamily A; member 1);Antibody of CD3e

Features and benefits

Short Overview:
Purity≥90% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
Species reactivity(Reacts with): Human
Isotype: Human IgG1

Application:

Item Number

Ab175605

Grouped product items
SKU	Size	Availability	Price
Ab175605-100μg	100μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$59.90
Ab175605-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$279.90
Ab175605-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$689.90
Ab175605-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,109.90

Purity≥90% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

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Basic Description

Product Name	Mosunetuzumab (anti-CD20&CD3e) - Primary antibody, specific to MS4A1 & CD3E, Human IgG1
Synonyms	BTCT4465A;CD20-TDB;Lunsumio,mosunetuzumab-axgb;RG-7828;RO7030816
Specifications & Purity	ExactAb™, Low Endotoxin, Azide Free, Carrier Free, Validated, Recombinant, ≥90%(SDS-PAGE&SEC), Lot by Lot
Specificity	MS4A1 & CD3E
Conjugation	Unconjugated
Grade	Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type	BINDING AGENT
Mechanism of action	Antibody of CD20 (membrane-spanning 4-domains; subfamily A; member 1);Antibody of CD3e
Product Description	Mosunetuzumab (anti-CD20 & CD3e) is a full-length, fully humanized immunoglobulin G1 (IgG1) T-cell-dependent bispecific (TDB) antibody targeting CD20 (B cells) and CD3 (T cells). Mosunetuzumab (anti-CD20 & CD3e) redirects T cells to engage and eliminate malignant B cells and can be used for the research of relapsed or refractory (R/R) B-cell non-Hodgkin lymphomas (B-NHLs). Purity ≥90% (SDS-PAGE&SEC) Endotoxin Level ≤1.0EU/mg

Product Properties

Isotype	Human IgG1
Light Chain Type	kappa
SDS-PAGE	146.72 kDa
Purification Method	Protein A purified
Concentration	Lot by Lot
Storage Temp	Store at -80°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS	1905409-39-3

Associated Targets

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

References

1. Sun LL, Ellerman D, Mathieu M, Hristopoulos M, Chen X, Li Y, Yan X, Clark R, Reyes A, Stefanich E et al.. (2015) Anti-CD20/CD3 T cell-dependent bispecific antibody for the treatment of B cell malignancies.. Sci Transl Med, 7 (287): (287ra70). [PMID:25972002]
2. Ferl GZ, Reyes A, Sun LL, Cheu M, Oldendorp A, Ramanujan S, Stefanich EG. (2018) A Preclinical Population Pharmacokinetic Model for Anti-CD20/CD3 T-Cell-Dependent Bispecific Antibodies.. Clin Transl Sci, 11 (3): (296-304). [PMID:29351372]
3. Hosseini I, Gadkar K, Stefanich E, Li CC, Sun LL, Chu YW, Ramanujan S. (2020) Mitigating the risk of cytokine release syndrome in a Phase I trial of CD20/CD3 bispecific antibody mosunetuzumab in NHL: impact of translational system modeling.. NPJ Syst Biol Appl, 6 (1): (28). [PMID:32859946]
4. Budde LE, Assouline S, Sehn LH, Schuster SJ, Yoon SS, Yoon DH, Matasar MJ, Bosch F, Kim WS, Nastoupil LJ et al.. (2022) Single-Agent Mosunetuzumab Shows Durable Complete Responses in Patients With Relapsed or Refractory B-Cell Lymphomas: Phase I Dose-Escalation Study.. J Clin Oncol, 40 (5): (481-491). [PMID:34914545]
5. Kang C. (2022) Mosunetuzumab: First Approval.. Drugs, 82 (11): (1229-1234). [PMID:35947358]

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Basic Description