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Moxifloxacin HCl - ≥99%, high purity , Bacterial DNA gyrase inhibitor, CAS No.186826-86-8, Bacterial DNA gyrase inhibitor
Basic Description Synonyms 1-Cyclopropyl-6-fluoro-7-((4aS,7aS)-hexahydro-1H-pyrrolo[3,4-b]pyridin-6(2H)-yl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylicacidhydrochloride | MOXIFLOXACIN HCL [VANDF] | Q368941 | 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-met Specifications & Purity ≥99% Biochemical and Physiological Mechanisms Moxifloxacin Hydrochloride is the hydrochloride salt preparation of Moxifloxacin, an 8-methoxy-fluoroquinone compound with broad-spectrum bactericidal activity against gram-positive and gram-negative strains. 8-methoxy-fluoroquinones are described to inhi Storage Temp Store at 2-8°C Shipped In Wet ice Action Type INHIBITOR Mechanism of action Bacterial DNA gyrase inhibitor Product Description Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial agent. An antibacterial agent that inhibits the activities of Topo II (DNA gyrase) and topoisomerase IV.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 7-[(4aS,7aS)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid;hydrochloride INCHI InChI=1S/C21H24FN3O4.ClH/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24;/h7,9,11-12,16,23H,2-6,8,10H2,1H3,(H,27,28);1H/t11-,16+;/m0./s1 InChi Key IDIIJJHBXUESQI-DFIJPDEKSA-N Canonical SMILES COC1=C2C(=CC(=C1N3CC4CCCNC4C3)F)C(=O)C(=CN2C5CC5)C(=O)O.Cl Isomeric SMILES COC1=C2C(=CC(=C1N3C[C@@H]4CCCN[C@@H]4C3)F)C(=O)C(=CN2C5CC5)C(=O)O.Cl RTECS VB1983750 Alternate CAS 151096-09-2 PubChem CID 101526 Molecular Weight 437.89 Beilstein 8377447
Chemical and Physical Properties Solubility Soluble in water (24 mg/ml), DMSO (88 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C). Melt Point(°C) 323.9-325°C
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H319: Causes serious eye irritation
H412: Harmful to aquatic life with long lasting effects
H302: Harmful if swallowed
Precautionary Statements P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P301+P317: IF SWALLOWED: Get medical help.
P337+P317: If eye irritation persists: Get medical help.
RTECS VB1983750
Citations of This Product 1. Ayesha Younas, Zhuolin Dong, Ziye Hou, Muhammad Asad, Mengru Li, Nan Zhang. (2023) A chitosan/fucoidan nanoparticle-loaded pullulan microneedle patch for differential drug release to promote wound healing. CARBOHYDRATE POLYMERS, 306 (120593). [PMID:36746584 ] 2. Fan Mo, Yi Liu, Yingyin Xu, Qingsen He, Pengfei Sun, Xiaoping Dong. (2022) Photocatalytic elimination of moxifloxacin by two-dimensional graphitic carbon nitride nanosheets: Enhanced activity, degradation mechanism and potential practical application. SEPARATION AND PURIFICATION TECHNOLOGY, 292 (121067). [PMID: ]
References 1. Ayesha Younas, Zhuolin Dong, Ziye Hou, Muhammad Asad, Mengru Li, Nan Zhang. (2023) A chitosan/fucoidan nanoparticle-loaded pullulan microneedle patch for differential drug release to promote wound healing. CARBOHYDRATE POLYMERS, 306 (120593). [PMID:36746584 ] 2. Fan Mo, Yi Liu, Yingyin Xu, Qingsen He, Pengfei Sun, Xiaoping Dong. (2022) Photocatalytic elimination of moxifloxacin by two-dimensional graphitic carbon nitride nanosheets: Enhanced activity, degradation mechanism and potential practical application. SEPARATION AND PURIFICATION TECHNOLOGY, 292 (121067). [PMID: ]
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