MP A08 - 97%, high purity , CAS No.219832-49-2, Inhibitor of sphingosine kinase 1;Inhibitor of sphingosine kinase 2

Item Number
M288047
Grouped product items
SKUSizeAvailabilityPrice Qty
M288047-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$68.90
M288047-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$107.90
M288047-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$243.90
M288047-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$385.90
M288047-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$682.90

Selective ATP competitive SphK1 and 2 inhibitor; cell permeable

Basic Description

Specifications & PurityMoligand™, ≥97%
Biochemical and Physiological MechanismsSelective ATP competitive sphingosine kinase 2 and 1 (SphK2/1) inhibitor (Kivalues are 6.9 and 27μM, respectively). Exhibits selectivity for SphK 1 and 2 over other kinases. Inhibits cellular S1P production and increases sphingosine and ceramide levelsin
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of sphingosine kinase 1;Inhibitor of sphingosine kinase 2

Associated Targets(Human)

SPHK2 Tchem Sphingosine kinase 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SPHK1 Tchem Sphingosine kinase 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SPHK2 Tchem Sphingosine kinase 2 (1579 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SPHK1 Tchem Sphingosine kinase 1 (1990 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 4-methyl-N-[2-[[2-[(4-methylphenyl)sulfonylamino]phenyl]iminomethyl]phenyl]benzenesulfonamide
INCHI InChI=1S/C27H25N3O4S2/c1-20-11-15-23(16-12-20)35(31,32)29-25-8-4-3-7-22(25)19-28-26-9-5-6-10-27(26)30-36(33,34)24-17-13-21(2)14-18-24/h3-19,29-30H,1-2H3
InChi Key FLDBNMYJUMAXDQ-UHFFFAOYSA-N
Canonical SMILES CC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C=NC3=CC=CC=C3NS(=O)(=O)C4=CC=C(C=C4)C
Isomeric SMILES CC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C=NC3=CC=CC=C3NS(=O)(=O)C4=CC=C(C=C4)C
PubChem CID 420266
NSC Number 122314
Molecular Weight 519.64

Certificates

Certificate of Analysis(COA)

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5 results found

Lot NumberCertificate TypeDateItem
C23311134Certificate of AnalysisJan 31, 2023 M288047
C23311135Certificate of AnalysisJan 31, 2023 M288047
C23311136Certificate of AnalysisJan 31, 2023 M288047
C23311137Certificate of AnalysisJan 31, 2023 M288047
C23311138Certificate of AnalysisJan 31, 2023 M288047

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 51.96, Max Conc. mM: 100

Related Documents

References

1. Pitman MR, Powell JA, Coolen C, Moretti PA, Zebol JR, Pham DH, Finnie JW, Don AS, Ebert LM, Bonder CS et al..  (2015)  A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties..  Oncotarget,  (9): (7065-83).  [PMID:25788259]

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