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MP-A08 , CAS No.M612003, Inhibitor of sphingosine kinase 1;Inhibitor of sphingosine kinase 2

Item Number
M612003
Grouped product items
SKUSizeAvailabilityPrice Qty
M612003-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
M612003-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,001.90

Basic Description

Specifications & PurityMoligand™
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of sphingosine kinase 1;Inhibitor of sphingosine kinase 2

Associated Targets(Human)

SPHK2 Tchem Sphingosine kinase 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SPHK1 Tchem Sphingosine kinase 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SPHK2 Tchem Sphingosine kinase 2 (1579 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences
Sphingosine kinase 2 inhibitorINHIBITORALA3023Sphingosine kinase 2SINGLE PROTEINHomo sapiens

PubMed: [1] , [2] , [3]


Names and Identifiers

INCHI InChI=1S/C27H25N3O4S2/c1-20-11-15-23(16-12-20)35(31,32)29-25-8-4-3-7-22(25)19-28-26-9-5-6-10-27(26)30-36(33,34)24-17-13-21(2)14-18-24/h3-19,29-30H,1-2H3/b28-19+
InChi Key FLDBNMYJUMAXDQ-TURZUDJPSA-N
Canonical SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccccc1/N=C/c1ccccc1NS(=O)(=O)c1ccc(cc1)C
Isomeric SMILES CC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C=NC3=CC=CC=C3NS(=O)(=O)C4=CC=C(C=C4)C
PubChem CID 420266

Certificates

C of A & Other Certificates

Related Documents

References

1. Pitman MR, Powell JA, Coolen C, Moretti PA, Zebol JR, Pham DH, Finnie JW, Don AS, Ebert LM, Bonder CS et al..  (2015)  A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties..  Oncotarget,  (9): (7065-83).  [PMID:25788259] [10.1021/op500134e]

Solution Calculators