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MPO-IN-28 - 98%, high purity , CAS No.37836-90-1, Inhibitor of myeloperoxidase

Moligand™
≥98%

CAS#: 37836-90-1
Formula: C₁₁H₁₃N₅O
Molecular Weight: 231.25
PubChem CID: 2835211

Item Number

M412317

Grouped product items
SKU	Size	Availability	Price
M412317-5mg	5mg	In stock	$162.90
M412317-25mg	25mg	In stock	$733.90
M412317-100mg	100mg	In stock	$2,640.90
M412317-250mg	250mg	In stock	$5,941.90

Peroxidases Inhibitors

View related series

myeloperoxidase Inhibitor

Basic Description

Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	MPO-IN-28 (Compound 28) is an inhibitor of myeloperoxidase (MPO) with IC50 of 44 nM.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of myeloperoxidase
Product Description	Information MPO-IN-28 MPO-IN-28 (Compound 28) is an inhibitor of myeloperoxidase (MPO) with IC50 of 44 nM. Targets MPO (Cell-free assay) 44 nM

ALogP

1.14

HBD Count

Rotatable Bond

Associated Targets

LPO Tbio Lactoperoxidase 0 Activities

Discover Target: LPO

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MPO Tchem Myeloperoxidase 3 Activities

Discover Target: MPO

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-(7-methoxy-4-methylquinazolin-2-yl)guanidine
INCHI	InChI=1S/C11H13N5O/c1-6-8-4-3-7(17-2)5-9(8)15-11(14-6)16-10(12)13/h3-5H,1-2H3,(H4,12,13,14,15,16)
InChi Key	ZJBMSSBTCGJZEE-UHFFFAOYSA-N
Canonical SMILES	CC1=C2C=CC(=CC2=NC(=N1)N=C(N)N)OC
Isomeric SMILES	CC1=C2C=CC(=CC2=NC(=N1)N=C(N)N)OC
PubChem CID	2835211
MeSH Entry Terms	2-(7-methoxy-4-methylquinazolin-2-yl)guanidine
Molecular Weight	231.25

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
J2214624	Certificate of Analysis	Jun 17, 2022	M412317
J2214625	Certificate of Analysis	Jun 17, 2022	M412317
J2214626	Certificate of Analysis	Jun 17, 2022	M412317
J2214628	Certificate of Analysis	Jun 17, 2022	M412317

Solubility

Solubility (25°C) In vitro DMSO: 46 mg/mL (198.91 mM); Water: Insoluble; Ethanol: Insoluble;

DMSO(mg / mL) Max Solubility

DMSO(mM) Max Solubility

198.918918918919

Water(mg / mL) Max Solubility

＜1

References

1. Soubhye J, Chikh Alard I, Aldib I, Prévost M, Gelbcke M, De Carvalho A, Furtmüller PG, Obinger C, Flemmig J, Tadrent S et al.. (2017) Discovery of Novel Potent Reversible and Irreversible Myeloperoxidase Inhibitors Using Virtual Screening Procedure.. J Med Chem, 60 (15): (6563-6586). [PMID:28671460]

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