Basic Description

Synonyms	MPP+ iodide \| 36913-39-0 \| 1-Methyl-4-phenylpyridinium iodide \| N-Methyl-4-phenylpyridinium iodide \| 1-Methyl-4-phenylpyridin-1-ium iodide \| Cyperquat iodide \| MPP+ (iodide) \| 1-methyl-4-phenylpyridin-1-ium;iodide \| Pyridinium, 1-methyl-4-phenyl-, iodide \| CHEMBL271379 \| N70
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	MPP+ iodide is an active metabolite of dopaminergic neurotoxin MPTP.Dopaminergic selective neurotoxin. Active MPTP metabolite. Interferes with oxidative phosphorylation and induces mitochondrial dysfunction. Deplete cellular ATP. Shows Parkinson effects i
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	Product Describtion: 1-Methyl-4-phenylpyridinium (MPP+) induces neurotoxicity by inhibiting mitochondrial redox functions in the striatal synaptosomes. It is a potential neurotoxin and induces Parkinson′s disease in animal models. It mediates apoptosis by the generation of reactive oxygen species in cerebellar granule neurons and neuroblastoma cells. MPP+ modulates the distribution of dopamine. It elicits neurotoxicity by activating neuronal nitric oxide synthase (nNOS), resulting in excess nitric oxide. Product Application： MPP+ iodide has been used: to induce oxidative stress in zebrafish embryos for the inhibition of glutamate uptake in mitochondria of astrocytes in testing cell viability using MTT (3 (4,5-dimethylthiazol)-2-yl-2,5-diphenyltetrazolium bromide) in microglia (BV2) cells

Associated Targets(Human)

SLC18A2 Tclin Synaptic vesicular amine transporter (118 Activities)

Discover Target: SLC18A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SH-SY5Y (11521 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	1-methyl-4-phenylpyridin-1-ium;iodide
INCHI	InChI=1S/C12H12N.HI/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-10H,1H3;1H/q+1;/p-1
InChi Key	RFDFRDXIIKROAI-UHFFFAOYSA-M
Canonical SMILES	C[N+]1=CC=C(C=C1)C2=CC=CC=C2.[I-]
Isomeric SMILES	C[N+]1=CC=C(C=C1)C2=CC=CC=C2.[I-]
WGK Germany	3
RTECS	UU6580000
PubChem CID	10924457
UN Number	2811
Packing Group	II
Molecular Weight	297.13

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Sensitivity	light ＆ Moisture sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H301:Toxic if swallowed H311:Toxic in contact with skin H331:Toxic if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P361+P364:Take off immediately all contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P316:Get emergency medical help immediately. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	UU6580000
Class	6.1

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Chao Guo, Junrong Zhu, Jingwen Wang, Jialin Duan, Shanbo Ma, Ying Yin, Wei Quan, Wei Zhang, Yue Guan, Yi Ding, Aidong Wen, Yingdong Zhang. (2019) Neuroprotective effects of protocatechuic aldehyde through PLK2/p-GSK3β/Nrf2 signaling pathway in both in vivo and in vitro models of Parkinson's disease. Aging-US, 11 (21): ( 9424–9441). [PMID:31697645] [10.18632/aging.102394]
2. Yun Yu, Xiu-Yuan Lang, Xi-Xi Li, Run-Ze Gu, Qing-Shan Liu, Rongfeng Lan, Xiao-Yan Qin. (2019) 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside attenuates MPP+/MPTP-induced neurotoxicity in vitro and in vivo by restoring the BDNF-TrkB and FGF2-Akt signaling axis and inhibition of apoptosis. Food & Function, 10 (9): (6009-6019). [PMID:31482900] [10.1039/C9FO01309A]

References

1. Chao Guo, Junrong Zhu, Jingwen Wang, Jialin Duan, Shanbo Ma, Ying Yin, Wei Quan, Wei Zhang, Yue Guan, Yi Ding, Aidong Wen, Yingdong Zhang. (2019) Neuroprotective effects of protocatechuic aldehyde through PLK2/p-GSK3β/Nrf2 signaling pathway in both in vivo and in vitro models of Parkinson's disease. Aging-US, 11 (21): ( 9424–9441). [PMID:31697645] [10.18632/aging.102394]
2. Yun Yu, Xiu-Yuan Lang, Xi-Xi Li, Run-Ze Gu, Qing-Shan Liu, Rongfeng Lan, Xiao-Yan Qin. (2019) 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside attenuates MPP+/MPTP-induced neurotoxicity in vitro and in vivo by restoring the BDNF-TrkB and FGF2-Akt signaling axis and inhibition of apoptosis. Food & Function, 10 (9): (6009-6019). [PMID:31482900] [10.1039/C9FO01309A]

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MPP+ iodide - 10mM in DMSO, high purity , CAS No.36913-39-0