MRK 016 - ≥98%(HPLC), high purity , CAS No.342652-67-9, Allosteric modulator of GABA A receptor α1 subunit;Allosteric modulator of GABA A receptor α2 subunit;Allosteric modulator of GABA A receptor α3 subunit;Allosteric modulator of GABA A receptor α5 subunit

Item Number

M286670

• Synonyms: MS-25900 | NSC51108 | GTPL4257 | BCP18257 | DL-Isoleucine, cell culture tested | UNII-TXZ4DVJ9MF | 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)pyrazolo[1,5-d][1,2,4]-triazine | MRK 016 | SCHEMBL2461269 | DTXSID60426080
• Specifications & Purity: Moligand™, ≥98%(HPLC)
• Biochemical and Physiological Mechanisms: GABAAreceptor inverse agonist selective for theα5-subtype (EC50= 3 nM). Exhibits affinity at benzodiazepine binding site of recombinant human GABAAreceptors (Kivalues are 0.77 nM, 0.83 nM, 0.85 nM and 1.4 nM forα3-,α1-,α2-, andα5-containing respectively).
• Storage Temp: Store at 2-8°C
• Shipped In: Wet ice
• Grade: Moligand™
• Action Type: ALLOSTERIC MODULATOR
• Mechanism of action: Allosteric modulator of GABA A receptor α1 subunit;Allosteric modulator of GABA A receptor α2 subunit;Allosteric modulator of GABA A receptor α3 subunit;Allosteric modulator of GABA A receptor α5 subunit