MRK 016 - ≥98%(HPLC), high purity , CAS No.342652-67-9, Allosteric modulator of GABA A receptor α1 subunit;Allosteric modulator of GABA A receptor α2 subunit;Allosteric modulator of GABA A receptor α3 subunit;Allosteric modulator of GABA A receptor α5 subunit

Item Number

M286670

• Synonyms: MRK-016|MRK 016|783331-24-8|342652-67-9|MRK016|TXZ4DVJ9MF|CHEMBL363211|3-[3-tert-butyl-2-[(2-methyl-1,2,4-triazol-3-yl)methoxy]pyrazolo[1,5-d][1,2,4]triazin-7-yl]-5-methyl-1,2-oxazole|3-(1,1-Dimethylethyl)-7-(5-methyl-3-isoxazolyl)-2-[(1-methyl-1H-1,2,4-t
• Specifications & Purity: Moligand™, ≥98%(HPLC)
• Biochemical and Physiological Mechanisms: GABAAreceptor inverse agonist selective for theα5-subtype (EC50= 3 nM). Exhibits affinity at benzodiazepine binding site of recombinant human GABAAreceptors (Kivalues are 0.77 nM, 0.83 nM, 0.85 nM and 1.4 nM forα3-,α1-,α2-, andα5-containing respectively).
• Storage Temp: Store at 2-8°C
• Shipped In: Wet ice
• Grade: Moligand™
• Action Type: ALLOSTERIC MODULATOR
• Mechanism of action: Allosteric modulator of GABA A receptor α1 subunit;Allosteric modulator of GABA A receptor α2 subunit;Allosteric modulator of GABA A receptor α3 subunit;Allosteric modulator of GABA A receptor α5 subunit