JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

྾

Home
Applications
Targets
Nuclear Receptors
Retinoic acid-related orphans
MRL-871 , CAS No.1392809-08-3, Agonist of RAR-related orphan receptor-γ

Skip to the end of the images gallery

Skip to the beginning of the images gallery

MRL-871 , CAS No.1392809-08-3, Agonist of RAR-related orphan receptor-γ

Moligand™

CAS#: 1392809-08-3
Formula: C₂₂H₁₂ClF₃N₂O₃
Molecular Weight: 444.79
PubChem CID: 68159303

Item Number

M612023

Grouped product items
SKU	Size	Availability	Price	Qty
M612023-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$229.90
M612023-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$916.90

View related series

RAR-related orphan receptor-γ Agonist

Basic Description

Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of RAR-related orphan receptor-γ

Associated Targets(Human)

RORC Tchem Nuclear receptor ROR-gamma (13 Activities)

Discover Target: RORC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)

Discover Target: PPARG

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	4-[1-[2-chloro-6-(trifluoromethyl)benzoyl]indazol-3-yl]benzoic acid
INCHI	InChI=1S/C22H12ClF3N2O3/c23-16-6-3-5-15(22(24,25)26)18(16)20(29)28-17-7-2-1-4-14(17)19(27-28)12-8-10-13(11-9-12)21(30)31/h1-11H,(H,30,31)
InChi Key	DANLZOIRUUHIIX-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C2C(=C1)C(=NN2C(=O)C3=C(C=CC=C3Cl)C(F)(F)F)C4=CC=C(C=C4)C(=O)O
Isomeric SMILES	C1=CC=C2C(=C1)C(=NN2C(=O)C3=C(C=CC=C3Cl)C(F)(F)F)C4=CC=C(C=C4)C(=O)O
PubChem CID	68159303
Molecular Weight	444.79

Database links

PubChem CID	68159303
ChEMBL Ligand	CHEMBL3598140
RCSB PDB Ligand	4F1
BindingDB Ligand	50106301
CAS Registry No.	1392809-08-3

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

References

1. Scheepstra M, Leysen S, van Almen GC, Miller JR, Piesvaux J, Kutilek V, van Eenennaam H, Zhang H, Barr K, Nagpal S et al.. (2015) Identification of an allosteric binding site for RORγt inhibition.. Nat Commun, 6 (13): (8833). [PMID:26640126] [10.1021/op500134e]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.