Skip to the beginning of the images gallery

MRS 1754 - ≥98%, high purity , CAS No.264622-58-4, Antagonist of A 1 receptor;Antagonist of A 2A receptor;Antagonist of A 2B receptor;Antagonist of A 3 receptor

Moligand™
≥98%

CAS#: 264622-58-4
Formula: C₂₆H₂₆N₆O₄
Molecular Weight: 486.52
EC Number: 806-672-9
PubChem CID: 6603931

Item Number

M275233

Grouped product items
SKU	Size	Availability	Price
M275233-5mg	5mg	In stock	$151.90
M275233-10mg	10mg	In stock	$205.90
M275233-25mg	25mg	In stock	$423.90
M275233-50mg	50mg	In stock	$763.90

Selective A 2B antagonist

View related series

A1 receptor Antagonist A2A receptor Antagonist A2B receptor Antagonist A3 receptor Antagonist

Basic Description

Synonyms	MRS 1754\|264622-58-4\|MRS1754\|MRS-1754\|N-(4-Cyanophenyl)-2-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,9-tetrahydro-1H-purin-8-yl)phenoxy)acetamide\|N-(4-cyanophenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide\|7E435V2DAH\|CHEMBL273807\|N-(4-Cyanophenyl
Specifications & Purity	≥98%
Storage Temp	Store at -20°C,Desiccated
Shipped In	Dry ice
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of A 1 receptor;Antagonist of A 2A receptor;Antagonist of A 2B receptor;Antagonist of A 3 receptor
Product Description	MRS 1754 is a selective antagonist radioligand for A2B adenosine receptor with very low affinity for A1 and A3 receptors of both humans and rats。

Associated Targets

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA2A Tclin Adenosine receptor A2a 2 Activities

Discover Target: ADORA2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA2B Tclin Adenosine receptor A2b 2 Activities

Discover Target: ADORA2B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA1 Tclin Adenosine receptor A1 2 Activities

Discover Target: ADORA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA3 Tchem Adenosine receptor A3 1 Activities

Discover Target: ADORA3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-(4-cyanophenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
INCHI	InChI=1S/C26H26N6O4/c1-3-13-31-24-22(25(34)32(14-4-2)26(31)35)29-23(30-24)18-7-11-20(12-8-18)36-16-21(33)28-19-9-5-17(15-27)6-10-19/h5-12H,3-4,13-14,16H2,1-2H3,(H,28,33)(H,29,30)
InChi Key	AJBBEYXFRYFVNM-UHFFFAOYSA-N
Canonical SMILES	CCCN1C2=C(C(=O)N(C1=O)CCC)NC(=N2)C3=CC=C(C=C3)OCC(=O)NC4=CC=C(C=C4)C#N
Isomeric SMILES	CCCN1C2=C(C(=O)N(C1=O)CCC)NC(=N2)C3=CC=C(C=C3)OCC(=O)NC4=CC=C(C=C4)C#N
Alternate CAS	264622-58-4
PubChem CID	6603931
MeSH Entry Terms	8-(4-(((4-cyanophenyl)carbamoylmethyl)oxy)phenyl)-1,3-di(ni-propyl)xanthine;MRS 1754;MRS-1754;MRS1754;N-(4-cyanophenyl)-2-(4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)-phenoxy)acetamide
Molecular Weight	486.52

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

4 results found

Lot Number	Certificate Type	Date	Item
B2320383	Certificate of Analysis	Dec 18, 2023	M275233
B2320426	Certificate of Analysis	Dec 18, 2023	M275233
B2320431	Certificate of Analysis	Dec 18, 2023	M275233
B2320511	Certificate of Analysis	Dec 18, 2023	M275233

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.

References

1. Yi X et al.. (2018) Adenosine receptors enhance the ATP-induced odontoblastic differentiation of human dental pulp cells.. Biochem Biophys Res Commun, 497 (3): (850-856). [PMID:29454963]
2. Basu M et al.. (2020) Increased host ATP efflux and its conversion to extracellular adenosine is crucial for establishing Leishmania infection.. J Cell Sci, 133 (7): [PMID:32079656]
3. Zhou Y et al.. (2019) MRS1754 inhibits proliferation and migration of bladder urothelial carcinoma by regulating mitogen-activated protein kinase pathway.. J Cell Physiol, 234 (7): (11360-11368). [PMID:30565699]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.