Grouped product items

SKU

Size

Availability

Price

Qty

M129552-10mg

10mg

Available within 4-8 weeks(?)

$75.90

M129552-50mg

50mg

Available within 4-8 weeks(?)

$227.90

Basic Description

Synonyms	MRS 2578\|711019-86-2\|MRS-2578\|MRS2578\|1,4-Di[3-(3-isothiocyanatophenyl)thioureido]butane\|1,1'-(butane-1,4-diyl)bis(3-(3-isothiocyanatophenyl)thiourea)\|CHEMBL1321988\|1-(3-isothiocyanatophenyl)-3-[4-[(3-isothiocyanatophenyl)carbamothioylamino]butyl]thiourea
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Selective antagonist of P2Y6nucleotide receptors; IC50values are 37 and 98 nM at human and rat P2Y6receptors respectively. Displays no activity at P2Y1, P2Y2, P2Y4and P2Y11receptors (IC50> 10μM). Inhibits agonist-induced cardiomyocyte contraction and UDP-
Storage Temp	Store at 2-8°C,Argon charged
Shipped In	Wet ice
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of P2Y 6 receptor
Note	卖完停产，不再备货
Product Description	MRS2578 is a potent P2Y6 receptor antagonist with IC50 of 37 nM, exhibits insignificant activity at P2Y1, P2Y2, P2Y4,and P2Y11 receptors. A selective P2Y66 receptor antagonist.

Associated Targets

CX3CR1 Tchem CX3C chemokine receptor 1 0 Activities

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CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

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GPR35 Tchem G-protein coupled receptor 35 0 Activities

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BRD4 Tchem Bromodomain-containing protein 4 0 Activities

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CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

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RUNX1 Tbio Runt-related transcription factor 1 0 Activities

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VDR Tclin Vitamin D3 receptor 0 Activities

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FFAR4 Tchem Free fatty acid receptor 4 0 Activities

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KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities

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HDAC6 Tclin Histone deacetylase 6 0 Activities

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FPR2 Tchem N-formyl peptide receptor 2 0 Activities

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FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

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CSNK1D Tchem Casein kinase I isoform delta 0 Activities

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S1PR1 Tclin Sphingosine 1-phosphate receptor 1 0 Activities

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TRIM24 Tchem Transcription intermediary factor 1-alpha 0 Activities

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ALOX15B Tchem Arachidonate 15-lipoxygenase B 0 Activities

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ALOX15 Tchem Arachidonate 15-lipoxygenase 0 Activities

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C5AR1 Tclin C5a anaphylatoxin chemotactic receptor 1 0 Activities

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BRPF1 Tchem Peregrin 0 Activities

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AURKA Tchem Aurora kinase A 0 Activities

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ADRB2 Tclin Beta-2 adrenergic receptor 0 Activities

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APLNR Tchem Apelin receptor 0 Activities

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ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

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ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

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ADGRF1 Tbio Adhesion G-protein coupled receptor F1 0 Activities

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AGTR1 Tclin Type-1 angiotensin II receptor 0 Activities

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ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

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MAPT Tclin Microtubule-associated protein tau 0 Activities

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GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

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GPR119 Tclin Glucose-dependent insulinotropic receptor 0 Activities

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GLP1R Tclin Glucagon-like peptide 1 receptor 0 Activities

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P2RY6 Tchem P2Y purinoceptor 6 4 Activities

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MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

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Names and Identifiers

IUPAC Name	1-(3-isothiocyanatophenyl)-3-[4-[(3-isothiocyanatophenyl)carbamothioylamino]butyl]thiourea
INCHI	InChI=1S/C20H20N6S4/c27-13-23-15-5-3-7-17(11-15)25-19(29)21-9-1-2-10-22-20(30)26-18-8-4-6-16(12-18)24-14-28/h3-8,11-12H,1-2,9-10H2,(H2,21,25,29)(H2,22,26,30)
InChi Key	QOHNRGHTJPFMSL-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=CC(=C1)N=C=S)NC(=S)NCCCCNC(=S)NC2=CC(=CC=C2)N=C=S
Isomeric SMILES	C1=CC(=CC(=C1)N=C=S)NC(=S)NCCCCNC(=S)NC2=CC(=CC=C2)N=C=S
WGK Germany	3
PubChem CID	16078986
Molecular Weight	472.67

Database links

PubChem CID	16078986
CAS Registry No.	711019-86-2
ChEMBL Ligand	CHEMBL1321988
GPCRdb Ligand	MRS2578

Certificates

Certificate of Analysis(COA)

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1 results found

Lot Number	Certificate Type	Date	Item
E1507018	Certificate of Analysis	Dec 09, 2022	M129552

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 23.63, Max Conc. mM: 50
Sensitivity	Moisture sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H301:Toxic if swallowed H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled H312:Harmful in contact with skin H332:Harmful if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.
WGK Germany	3

References

1. Sil P, Hayes CP, Reaves BJ, Breen P, Quinn S, Sokolove J, Rada B. (2017) P2Y6 Receptor Antagonist MRS2578 Inhibits Neutrophil Activation and Aggregated Neutrophil Extracellular Trap Formation Induced by Gout-Associated Monosodium Urate Crystals.. J Immunol, 198 (1): (428-442). [PMID:27903742]

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SKU	Size	Availability	Price	Qty
M129552-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$75.90
M129552-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$227.90

MRS 2578 - ≥98%, high purity , CAS No.711019-86-2, Antagonist of P2Y 6 receptor