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G protein-coupled receptors (GPCRs)
P2Y receptors
MRS4458 , CAS No.M612067, Antagonist of P2Y 14 receptor

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MRS4458 , CAS No.M612067, Antagonist of P2Y 14 receptor

Moligand™

PubChem CID: 134611895

Item Number

M612067

Grouped product items
SKU	Size	Availability	Price	Qty
M612067-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
M612067-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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P2Y14 receptor Antagonist

Basic Description

Synonyms	compound 20 [Yu et al., 2018]
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of P2Y 14 receptor

Associated Targets

HTR1D Tclin 5-hydroxytryptamine receptor 1D 0 Activities

Discover Target: HTR1D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OPRD1 Tclin Delta-type opioid receptor 0 Activities

Discover Target: OPRD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

P2RY14 Tchem P2Y purinoceptor 14 1 Activities

Discover Target: P2RY14

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-{5-[(3-aminopropyl)carbamoyl]thiophen-2-yl}-5-{4-[4-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-1-yl}benzoic acid
INCHI	InChI=1S/C24H20F3N5O3S/c25-24(26,27)17-4-2-14(3-5-17)19-13-32(31-30-19)18-11-15(10-16(12-18)23(34)35)20-6-7-21(36-20)22(33)29-9-1-8-28/h2-7,10-13H,1,8-9,28H2,(H,29,33)(H,34,35)
InChi Key	VYXSDIPOJBFWHQ-UHFFFAOYSA-N
Canonical SMILES	NCCCNC(=O)c1ccc(s1)c1cc(cc(c1)n1nnc(c1)c1ccc(cc1)C(F)(F)F)C(=O)O
Isomeric SMILES	C1=CC(=CC=C1C2=CN(N=N2)C3=CC(=CC(=C3)C(=O)O)C4=CC=C(S4)C(=O)NCCCN)C(F)(F)F
PubChem CID	134611895

Database links

GPCRdb Ligand	MRS4458
PubChem CID	134611895

Certificates

Certificate of Analysis(COA)

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References

1. Yu J, Ciancetta A, Dudas S, Duca S, Lottermoser J, Jacobson KA. (2018) Structure-Guided Modification of Heterocyclic Antagonists of the P2Y₁₄ Receptor.. J Med Chem, 61 (11): (4860-4882). [PMID:29767967]

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