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G protein-coupled receptors (GPCRs)
P2Y receptors
MRS4458 , CAS No.M612067, Antagonist of P2Y 14 receptor

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MRS4458 , CAS No.M612067, Antagonist of P2Y 14 receptor

Moligand™

PubChem CID: 134611895

Item Number

M612067

Grouped product items
SKU	Size	Availability	Price	Qty
M612067-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
M612067-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

P2Y14 receptor Antagonist

Basic Description

Synonyms	compound 20 [Yu et al., 2018]
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of P2Y 14 receptor

Associated Targets(Human)

P2RY14 Tchem P2Y purinoceptor 14 (1 Activities)

Discover Target: P2RY14

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR1D Tclin Serotonin 1d (5-HT1d) receptor (2897 Activities)

Discover Target: HTR1D

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OPRD1 Tclin Delta opioid receptor (15096 Activities)

Discover Target: OPRD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

P2RY14 Tchem Purinergic receptor P2Y14 (692 Activities)

Discover Target: P2RY14

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	3-{5-[(3-aminopropyl)carbamoyl]thiophen-2-yl}-5-{4-[4-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-1-yl}benzoic acid
INCHI	InChI=1S/C24H20F3N5O3S/c25-24(26,27)17-4-2-14(3-5-17)19-13-32(31-30-19)18-11-15(10-16(12-18)23(34)35)20-6-7-21(36-20)22(33)29-9-1-8-28/h2-7,10-13H,1,8-9,28H2,(H,29,33)(H,34,35)
InChi Key	VYXSDIPOJBFWHQ-UHFFFAOYSA-N
Canonical SMILES	NCCCNC(=O)c1ccc(s1)c1cc(cc(c1)n1nnc(c1)c1ccc(cc1)C(F)(F)F)C(=O)O
Isomeric SMILES	C1=CC(=CC=C1C2=CN(N=N2)C3=CC(=CC(=C3)C(=O)O)C4=CC=C(S4)C(=O)NCCCN)C(F)(F)F
PubChem CID	134611895

Database links

GPCRdb Ligand	MRS4458
PubChem CID	134611895

Certificates

Certificate of Analysis(COA)

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References

1. Yu J, Ciancetta A, Dudas S, Duca S, Lottermoser J, Jacobson KA. (2018) Structure-Guided Modification of Heterocyclic Antagonists of the P2Y₁₄ Receptor.. J Med Chem, 61 (11): (4860-4882). [PMID:29767967] [10.1021/acs.jmedchem.8b00168]

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