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MRT 10 - ≥98%, high purity , CAS No.330829-30-6
Smoothened (Smo) antagonist
Basic Description Synonyms EX-A7242 | J-019016 | MRT-10, >=98% (HPLC) | MS-28575 | 3,4,5-trimethoxy-N-({3-[(phenylcarbonyl)amino]phenyl}carbamothioyl)benzamide | AKOS000619111 | N-((3-Benzamidophenyl)carbamothioyl)-3,4,5-trimethoxybenzamide | n-(3-benzamidophenylcarbamothioyl)-3,4, Specifications & Purity ≥98% Biochemical and Physiological Mechanisms Smoothened (Smo) receptor antagonist (IC50= 0.5μM in HEK293 cells transiently expressing mouse Smo). Inhibits ShhN-induced Gli luciferase reporter activity in Shh-light 2 cells (IC50= 2.5μM); acts as an inverse agonist during nontranscriptional Hedgehog p Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description Product description
MRT-10 is a seven-transmembrane receptor smoothened (Smo) antagonist with an IC50 of 0.65 μM in the micromolar range in various Hedgehog (Hh) assays. MRT-10 binds to the Smo receptor at the level of the Bodipycyclopamine binding site. MRT-10 can be used for the research of cancer.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers Pubchem Sid 488191726 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488191726 IUPAC Name N-[(3-benzamidophenyl)carbamothioyl]-3,4,5-trimethoxybenzamide INCHI InChI=1S/C24H23N3O5S/c1-30-19-12-16(13-20(31-2)21(19)32-3)23(29)27-24(33)26-18-11-7-10-17(14-18)25-22(28)15-8-5-4-6-9-15/h4-14H,1-3H3,(H,25,28)(H2,26,27,29,33) InChi Key KVQVEZQDNHMQJV-UHFFFAOYSA-N Canonical SMILES COC1=CC(=CC(=C1OC)OC)C(=O)NC(=S)NC2=CC=CC(=C2)NC(=O)C3=CC=CC=C3 Isomeric SMILES COC1=CC(=CC(=C1OC)OC)C(=O)NC(=S)NC2=CC=CC(=C2)NC(=O)C3=CC=CC=C3 PubChem CID 1139102 Molecular Weight 465.52
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 46.55, Max Conc. mM: 100
Safety and Hazards(GHS) Pictogram(s) GHS09 , GHS05 Signal Danger Hazard Statements H318: Causes serious eye damage
H400: Very toxic to aquatic life
H410: Very toxic to aquatic life with long lasting effects
Precautionary Statements P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
P391: Collect spillage.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P305+P354+P338: IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing.
P317: Get emergency medical help.
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