MRTX0902 , CAS No.M612078, SOS Ras/Rac guanine nucleotide exchange factor 1

Item Number

M612078

Grouped product items
SKU	Size	Availability	Price	Qty
M612078-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$750.90
M612078-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,034.90

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Basic Description

Synonyms	MRTX0902 \| 2654743-22-1 \| MRTX-0902 \| CRG69FR93G \| UNII-CRG69FR93G \| CHEMBL5192659 \| (R)-2-Methyl-3-(1-((4-methyl-7-morpholinopyrido(3,4-d)pyridazin-1-yl)amino)ethyl)benzonitrile \| Benzonitrile, 2-methyl-3-((1R)-1-((4-methyl-7-(4-morpholinyl)pyrido(3,4-d)pyridazin-1-yl
Specifications & Purity	Moligand™
Grade	Moligand™
Mechanism of action	SOS Ras/Rac guanine nucleotide exchange factor 1

Associated Targets(Human)

SOS1 Tchem Son of sevenless homolog 1 (0 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MIA PaCa-2 (5949 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

INCHI	InChI=1S/C22H24N6O/c1-14-17(12-23)5-4-6-18(14)15(2)25-22-19-11-21(28-7-9-29-10-8-28)24-13-20(19)16(3)26-27-22/h4-6,11,13,15H,7-10H2,1-3H3,(H,25,27)/t15-/m1/s1
InChi Key	ILPWEAHQRAWJIU-OAHLLOKOSA-N
Canonical SMILES	C[C@@H](Nc1nnc(C)c2c1cc(nc2)N1CCOCC1)c1cccc(C#N)c1C
Isomeric SMILES	CC1=C(C=CC=C1[C@@H](C)NC2=NN=C(C3=CN=C(C=C32)N4CCOCC4)C)C#N
PubChem CID	156526655

PubChem CID

RCSB PDB Ligand

References

1. Ketcham JM, Haling J, Khare S, Bowcut V, Briere DM, Burns AC, Gunn RJ, Ivetac A, Kuehler J, Kulyk S et al.. (2022) Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein-Protein Interaction.. J Med Chem, 71 (13): (1755-70). [PMID:35833726] [10.1021/acs.jmedchem.2c00741]
2. Hillig RC, Sautier B, Schroeder J, Moosmayer D, Hilpmann A, Stegmann CM, Werbeck ND, Briem H, Boemer U, Weiske J et al.. (2019) Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.. Proc Natl Acad Sci USA, 116 (7): (2551-2560). [PMID:30683722] [10.1021/op500134e]
3. Hofmann MH, Gmachl M, Ramharter J, Savarese F, Gerlach D, Marszalek JR, Sanderson MP, Kessler D, Trapani F, Arnhof H et al.. (2021) BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition.. Cancer Discov, 11 (1): (142-157). [PMID:32816843] [10.1021/op500134e]

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Basic Description