MS31 , CAS No.2366264-12-0

Item Number

M648284

• Biochemical and Physiological Mechanisms: MS31 is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 potently inhibits the interactions between SPIN1 and H3K4me3 ( IC 50 =77 nM, AlphaLISA; 243 nM, FP). MS31 selectively binds Tudor
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads

Product Description

MS31 is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 potently inhibits the interactions between SPIN1 and H3K4me3 ( IC 50 =77 nM, AlphaLISA; 243 nM, FP). MS31 selectively binds Tudor domain II of SPIN1 ( K d =91 nM). MS31 potently inhibits binding of trimethyllysine-containing peptides to SPIN1. MS31 is not toxic to nontumorigenic cells

In Vitro

MS31 potently inhibits binding of trimethyllysine-containing peptides to SPIN1, displays high binding affinity, is highly selective for SPIN1 over other epigenetic readers and writers, directly engages SPIN1 in cells, and is not toxic to nontumorigenic cells. MS31 selectively binds tudor domain II of SPIN1. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: 77 nM (SPIN1 by AlphaLISA), 243 nM (SPIN1 by FP), Kd: 91 nM (SPIN1)