MSA 2 - 10mM in DMSO, high purity , CAS No.129425-81-6

Item Number

M421160

Grouped product items
SKU	Size	Availability	Price	Qty
M421160-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$118.90

Non-nucleotide STING agonist

Basic Description

Synonyms	MSA-2 \| 129425-81-6 \| 4-(5,6-dimethoxybenzo[b]thiophen-2-yl)-4-oxobutanoic acid \| 4-(5,6-dimethoxy-1-benzothiophen-2-yl)-4-oxobutanoic acid \| MSA2 \| MSA 2 \| SCHEMBL9208326 \| CHEMBL4434776 \| APCLRHPWFCQIMG-UHFFFAOYSA-N \| BDBM453551 \| EX-A4363 \| US10730849, Example 16 \| NSC828583 \|
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Non-nucleotide STING agonist (EC50values are 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively). Exhibits antitumor activity and stimulates interferon-β secretion in tumors. Induces tumor regression with durable antitumor immunity, and syner
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

KCNH2 Tclin HERG (29587 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

4T1 (1737 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CT26 (928 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Sting1 Stimulator of interferon genes protein (255 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	4-(5,6-dimethoxy-1-benzothiophen-2-yl)-4-oxobutanoic acid
INCHI	InChI=1S/C14H14O5S/c1-18-10-5-8-6-13(9(15)3-4-14(16)17)20-12(8)7-11(10)19-2/h5-7H,3-4H2,1-2H3,(H,16,17)
InChi Key	APCLRHPWFCQIMG-UHFFFAOYSA-N
Canonical SMILES	COC1=C(C=C2C(=C1)C=C(S2)C(=O)CCC(=O)O)OC
Isomeric SMILES	COC1=C(C=C2C(=C1)C=C(S2)C(=O)CCC(=O)O)OC
PubChem CID	23035251
Molecular Weight	294.32

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

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Basic Description