MSC1094308 - 99%, high purity , CAS No.2219320-08-6

Item Number

M651339

Grouped product items
SKU	Size	Availability	Price
M651339-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$95.90
M651339-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$150.90
M651339-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$300.90
M651339-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$510.90
M651339-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$870.90

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Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	MSC1094308 is a non-competitive and reversible VPS4B/p97 (VCP) (I/II type AAA ATPase) allosteric inhibitor, with IC 50 values of 0.71 μM and 7.2 μM for VPS4B and p97 , respectively. MSC1094308 inhibits the D2 ATPase activity by binding to a agentable
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	MSC1094308 is a non-competitive and reversible VPS4B/p97 (VCP) (I/II type AAA ATPase) allosteric inhibitor, with IC 50 values of 0.71 μM and 7.2 μM for VPS4B and p97 , respectively MSC1094308 inhibits the D2 ATPase activity by binding to a agentable hotspot of p97 . MSC1094308 can be used in study of cancer In Vitro MSC1094308 (10 µM; 8 h) induces accumulation of polyubiquitin as a biomarker for degradation inhibition in HCT116 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: HCT116 cells Concentration: 10 µM Incubation Time: 8 h Result: Led to accumulation of polyubiquitinated proteins (a biomarker for degradation inhibition). Form:Solid IC50& Target:IC50: 0.71 μM (VPS4B), 7.2 μM (p97)

Associated Targets(Human)

VPS4B Tchem Vacuolar protein sorting-associated protein 4B (2 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

VCP Tchem Transitional endoplasmic reticulum ATPase (895 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

VPS4B Tchem Vacuolar protein sorting-associated protein 4B (6 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	4,4-bis(4-fluorophenyl)-N-[(6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl)methyl]butan-1-amine
INCHI	InChI=1S/C29H29F3N2/c30-22-8-4-20(5-9-22)25(21-6-10-23(31)11-7-21)2-1-15-33-18-19-3-13-28-26(16-19)27-17-24(32)12-14-29(27)34-28/h4-12,14,17,19,25,33-34H,1-3,13,15-16,18H2
InChi Key	OCZIMUMAPGQEBH-UHFFFAOYSA-N
Canonical SMILES	C1CC2=C(CC1CNCCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)C5=C(N2)C=CC(=C5)F
Isomeric SMILES	C1CC2=C(CC1CNCCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)C5=C(N2)C=CC(=C5)F
PubChem CID	139035043
Molecular Weight	462.5

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Basic Description