Basic Description

Specifications & Purity	≥95%
Biochemical and Physiological Mechanisms	MT-802 is a potent PROTAC that induces Bruton's tyrosine kinase (BTK) knockdown. MT-802 recruits BTK to the cereblon E3 ubiquitin ligase complex to trigger BTK ubiquitination and degradation via the proteasome. MT-802 has potential for treatment of C481S
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Information MT-802 MT-802 is a potent PROTAC that induces Bruton's tyrosine kinase (BTK) knockdown. MT-802 recruits BTK to the cereblon E3 ubiquitin ligase complex to trigger BTK ubiquitination and degradation via the proteasome. MT-802 has potential for treatment of C481S mutant chronic lymphocytic leukemia (CLL). Targets BTK

Associated Targets(Human)

BTK Tclin Protein cereblon/Tyrosine-protein kinase BTK (75 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Pubchem Sid	488203030
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488203030
IUPAC Name	2-[2-[2-[4-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]ethoxy]ethoxy]-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]acetamide
INCHI	InChI=1S/C41H41N9O8/c42-37-35-36(25-6-9-29(10-7-25)58-28-4-2-1-3-5-28)47-50(38(35)44-24-43-37)27-14-16-48(17-15-27)18-19-56-20-21-57-23-34(52)45-26-8-11-30-31(22-26)41(55)49(40(30)54)32-12-13-33(51)46-39(32)53/h1-11,22,24,27,32H,12-21,23H2,(H,45,52)(H2,42,43,44)(H,46,51,53)
InChi Key	AJTLGUJXIKEZCQ-UHFFFAOYSA-N
Canonical SMILES	C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)NC(=O)COCCOCCN4CCC(CC4)N5C6=NC=NC(=C6C(=N5)C7=CC=C(C=C7)OC8=CC=CC=C8)N
Isomeric SMILES	C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)NC(=O)COCCOCCN4CCC(CC4)N5C6=NC=NC(=C6C(=N5)C7=CC=C(C=C7)OC8=CC=CC=C8)N
PubChem CID	138108326
Molecular Weight	787.82

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6 results found

Lot Number	Certificate Type	Date	Item
D2301708	Certificate of Analysis	Feb 02, 2023	M413690
D2301712	Certificate of Analysis	Feb 02, 2023	M413690
D2301713	Certificate of Analysis	Feb 02, 2023	M413690
D2301714	Certificate of Analysis	Feb 02, 2023	M413690
D2301722	Certificate of Analysis	Feb 02, 2023	M413690
D2301723	Certificate of Analysis	Feb 02, 2023	M413690

Solubility	Solubility (25°C) In vitro DMSO: 100 mg/mL (126.93 mM); Water: Insoluble; Ethanol: Insoluble;

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SKU	Size	Availability	Price
M413690-5mg	5mg	In stock	$484.90
M413690-25mg	25mg	In stock	$2,182.90
M413690-100mg	100mg	In stock	$4,107.90