Mubritinib (TAK 165) - ≥99%, high purity , Receptor protein-tyrosine kinase erbB-2 inhibitor, CAS No.366017-09-6, Receptor protein-tyrosine kinase erbB-2 inhibitor

Item Number

M129797

• Synonyms: Mubritinib|366017-09-6|Mubritinib (TAK 165)|TAK 165|TAK-165|TAK165|(E)-4-((4-(4-(1H-1,2,3-triazol-1-yl)butyl)phenoxy)methyl)-2-(4-(trifluoromethyl)styryl)oxazole|V734AZP9BR|1-(4-(4-((2-((1E)-2-(4-(Trifluoromethyl)phenyl)ethenyl)-4-oxazolyl)methoxy)phenyl)
• Specifications & Purity: Moligand™, ≥99%
• Biochemical and Physiological Mechanisms: TAK 165 is a potent Neu (HER2) and Cdc2 p34 inhibitor with IC50 of 6 nM and 0.2μM, respectively. TAK 165 also inhibits Cdk2 (p33cdk2) and Cdk5 (p33cdk5). TAK 165 displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. TAK 165 exhibits poten
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Receptor protein-tyrosine kinase erbB-2 inhibitor
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Product Description

Mubritinib (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM; no activity to EGFR, FGFR, PDGFR, JAK1, Src and Blk.
A selective, potent, and irreversible ErbB2 and EGFR inhibitor.