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Murizatoclax - 98%, high purity , CAS No.2245848-05-7

  • ≥98%
Item Number
M650158
Grouped product items
SKUSizeAvailabilityPrice Qty
M650158-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$890.90
M650158-500μg
500μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,780.90
M650158-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,850.90
View related series
Apoptosis Bcl-2 Family

Basic Description

Specifications & Purity≥98%
Biochemical and Physiological MechanismsMurizatoclax (AMG 397) is a potent, selective and orally active inhibitor of myeloid leukemia 1 (MCL-1) inhibitor, with a K i of 15 pM. Murizatoclax competitive binds to the BH3-binding groove of MCL1 with pro-apoptotic BCL-2 family members. Murizatoclax
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

Murizatoclax (AMG 397) is a potent, selective and orally active inhibitor of myeloid leukemia 1 (MCL-1) inhibitor, with a K i of 15 pM. Murizatoclax competitive binds to the BH3-binding groove of MCL1 with pro-apoptotic BCL-2 family members. Murizatoclax can be used for the research of cancer

In Vitro

AMG 397 potently disrupts the interaction between MCL1 and BIM in OPM2 cells, induces clear increases in Caspase-3/7 activity within one hour. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Murizatoclax (25-50 mg/kg; p.o. once or twice weekly) exhibits significant tumor regressions in mice bearing OPM2 xenografts. Murizatoclax (10-60 mg/kg; p.o. twice weekly) achieves 47% MOLM-13 orthotopic tumor growth inhibition (TGI), 99% TGI and 75% regression at the dose of 10, 30 and 60 mg/kg, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:MCL1 15 pM (Ki)

Associated Targets(Human)

BCL2L1 Tchem Apoptosis regulator Bcl-X (2604 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCL2 Tclin Apoptosis regulator Bcl-2 (3787 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCL1 Tchem Induced myeloid leukemia cell differentiation protein Mcl-1 (3820 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPM-2 (216 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences
Apoptosis regulator Bcl-X inhibitorINHIBITORALA4625Apoptosis regulator Bcl-XSINGLE PROTEINHomo sapiens

PubMed: [1] , [2] , [3]


Apoptosis regulator Bcl-X inhibitorINHIBITORALA4625Apoptosis regulator Bcl-XSINGLE PROTEINHomo sapiensOccupies the BH3 binding groove of Bcl-xL, Bcl-2, and Bcl-w.

PubMed: [1] , [2]


Apoptosis regulator Bcl-2 inhibitorINHIBITORALA4860Apoptosis regulator Bcl-2SINGLE PROTEINHomo sapiens

FDA: [1]


Apoptosis regulator Bcl-2 inhibitorINHIBITORALA4860Apoptosis regulator Bcl-2SINGLE PROTEINHomo sapiensBH3 binding groove

PubMed: [1] , [2] , [3]


Apoptosis regulator Bcl-2 inhibitorINHIBITORALA4860Apoptosis regulator Bcl-2SINGLE PROTEINHomo sapiensOccupies the BH3 binding groove of Bcl-xL, Bcl-2, and Bcl-w.

PubMed: [1] , [2]


Apoptosis regulator Bcl-2 inhibitorINHIBITORALA4860Apoptosis regulator Bcl-2SINGLE PROTEINHomo sapiens

PubMed: [1]


Induced myeloid leukemia cell differentiation protein Mcl-1 inhibitorINHIBITORALA4361Induced myeloid leukemia cell differentiation protein Mcl-1SINGLE PROTEINHomo sapiens

PubMed: [1] , [2] , [3]


Names and Identifiers

Canonical SMILES C[C@H]1C/C=C/[C@@]([C@@H]2CC[C@H]2CN3C[C@@]4(CCCC5=C4C=CC(=C5)Cl)COC6=C3C=C(C=C6)C(=O)NS(=O)(=O)[C@@H]1C)(CN7CCN8CCCC[C@@H]8C7)OC
Isomeric SMILES C[C@H]1C/C=C/[C@@]([C@@H]2CC[C@H]2CN3C[C@@]4(CCCC5=C4C=CC(=C5)Cl)COC6=C3C=C(C=C6)C(=O)NS(=O)(=O)[C@@H]1C)(CN7CCN8CCCC[C@@H]8C7)OC
PubChem CID 138669688
Molecular Weight 765.44

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilityDMSO : 10 mg/mL (13.06 mM; Need ultrasonic)

Related Documents

Solution Calculators