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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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M650158-100μg | 100μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $890.90 | |
M650158-500μg | 500μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,780.90 | |
M650158-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,850.90 |
Specifications & Purity | ≥98% |
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Biochemical and Physiological Mechanisms | Murizatoclax (AMG 397) is a potent, selective and orally active inhibitor of myeloid leukemia 1 (MCL-1) inhibitor, with a K i of 15 pM. Murizatoclax competitive binds to the BH3-binding groove of MCL1 with pro-apoptotic BCL-2 family members. Murizatoclax |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | Murizatoclax (AMG 397) is a potent, selective and orally active inhibitor of myeloid leukemia 1 (MCL-1) inhibitor, with a K i of 15 pM. Murizatoclax competitive binds to the BH3-binding groove of MCL1 with pro-apoptotic BCL-2 family members. Murizatoclax can be used for the research of cancer In Vitro AMG 397 potently disrupts the interaction between MCL1 and BIM in OPM2 cells, induces clear increases in Caspase-3/7 activity within one hour. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Murizatoclax (25-50 mg/kg; p.o. once or twice weekly) exhibits significant tumor regressions in mice bearing OPM2 xenografts. Murizatoclax (10-60 mg/kg; p.o. twice weekly) achieves 47% MOLM-13 orthotopic tumor growth inhibition (TGI), 99% TGI and 75% regression at the dose of 10, 30 and 60 mg/kg, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:MCL1 15 pM (Ki) |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Apoptosis regulator Bcl-X inhibitor | INHIBITOR | ALA4625 | Apoptosis regulator Bcl-X | SINGLE PROTEIN | Homo sapiens | ||
Apoptosis regulator Bcl-X inhibitor | INHIBITOR | ALA4625 | Apoptosis regulator Bcl-X | SINGLE PROTEIN | Homo sapiens | Occupies the BH3 binding groove of Bcl-xL, Bcl-2, and Bcl-w. | |
Apoptosis regulator Bcl-2 inhibitor | INHIBITOR | ALA4860 | Apoptosis regulator Bcl-2 | SINGLE PROTEIN | Homo sapiens | FDA: [1] | |
Apoptosis regulator Bcl-2 inhibitor | INHIBITOR | ALA4860 | Apoptosis regulator Bcl-2 | SINGLE PROTEIN | Homo sapiens | BH3 binding groove | |
Apoptosis regulator Bcl-2 inhibitor | INHIBITOR | ALA4860 | Apoptosis regulator Bcl-2 | SINGLE PROTEIN | Homo sapiens | Occupies the BH3 binding groove of Bcl-xL, Bcl-2, and Bcl-w. | |
Apoptosis regulator Bcl-2 inhibitor | INHIBITOR | ALA4860 | Apoptosis regulator Bcl-2 | SINGLE PROTEIN | Homo sapiens | PubMed: [1] | |
Induced myeloid leukemia cell differentiation protein Mcl-1 inhibitor | INHIBITOR | ALA4361 | Induced myeloid leukemia cell differentiation protein Mcl-1 | SINGLE PROTEIN | Homo sapiens |
Canonical SMILES | C[C@H]1C/C=C/[C@@]([C@@H]2CC[C@H]2CN3C[C@@]4(CCCC5=C4C=CC(=C5)Cl)COC6=C3C=C(C=C6)C(=O)NS(=O)(=O)[C@@H]1C)(CN7CCN8CCCC[C@@H]8C7)OC |
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Isomeric SMILES | C[C@H]1C/C=C/[C@@]([C@@H]2CC[C@H]2CN3C[C@@]4(CCCC5=C4C=CC(=C5)Cl)COC6=C3C=C(C=C6)C(=O)NS(=O)(=O)[C@@H]1C)(CN7CCN8CCCC[C@@H]8C7)OC |
PubChem CID | 138669688 |
Molecular Weight | 765.44 |
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Solubility | DMSO : 10 mg/mL (13.06 mM; Need ultrasonic) |
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