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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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M412873-1mg | 1mg | In stock | $17.90 | |
M412873-5mg | 5mg | In stock | $74.90 | |
M412873-25mg | 25mg | In stock | $308.90 | |
M412873-50mg | 50mg | In stock | $513.90 | |
M412873-100mg | 100mg | Available within 1-2 weeks(?) Item is derived from our semi-finished stock and is processed in 1-2 weeks. | $925.90 |
TNF-α Selective Inhibitors | Activators | Antagonists
Synonyms | Myrislignan | 171485-39-5 | CHEMBL4085435 | (aR)-alpha-[(1S)-1-[2,6-Dimethoxy-4-(2-propen-1-yl)phenoxy]ethyl]-4-hydroxy-3-methoxybenzenemethanol | (-)-(1R,2S)-Myrislignan | DTXSID30333494 | HY-N0608 | BDBM50242967 | MFCD13195532 | s3261 | AKOS015909818 | AC-34668 | AS-77374 | CS-0 |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Myrislignan, a lignan isolated from Myristica fragrans Houtt, possesses anti-inflammatory activities. Myrislignan inhibits interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α). Myrislignan significantly inhibits the expressions of inducible NO syntha |
Storage Temp | Protected from light,Store at -20°C |
Shipped In | Ice chest + Ice pads |
Note | 1mg卖完停产,不再备货 |
Product Description | Information Myrislignan, a lignan isolated fromMyristica fragrans Houtt, possesses anti-inflammatory activities. Myrislignan inhibitsinterleukin-6 (IL-6)andtumour necrosis factor-α (TNF-α). Myrislignan significantly inhibits the expressions ofinducible NO synthase (iNOS)andcyclooxygenase-2 (COX-2)dose-dependently in LPS-stimulated macrophage cells. Myrislignan inhibits theNF-κBsignalling pathway activation. Targets IL-6 ; TNF-α ; iNOS ; COX-2 ; NF-κB |
ALogP | 3.98 |
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HBD Count | 2 |
Rotatable Bond | 9 |
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Pubchem Sid | 488199898 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488199898 |
IUPAC Name | 4-[(1R,2S)-2-(2,6-dimethoxy-4-prop-2-enylphenoxy)-1-hydroxypropyl]-2-methoxyphenol |
INCHI | InChI=1S/C21H26O6/c1-6-7-14-10-18(25-4)21(19(11-14)26-5)27-13(2)20(23)15-8-9-16(22)17(12-15)24-3/h6,8-13,20,22-23H,1,7H2,2-5H3/t13-,20-/m0/s1 |
InChi Key | ULZFTGWWPHYLGI-RBZFPXEDSA-N |
Canonical SMILES | CC(C(C1=CC(=C(C=C1)O)OC)O)OC2=C(C=C(C=C2OC)CC=C)OC |
Isomeric SMILES | C[C@@H]([C@@H](C1=CC(=C(C=C1)O)OC)O)OC2=C(C=C(C=C2OC)CC=C)OC |
PubChem CID | 21636106 |
Molecular Weight | 374.43 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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D23141944 | Certificate of Analysis | Mar 06, 2023 | M412873 |
D23141954 | Certificate of Analysis | Mar 06, 2023 | M412873 |
D23141982 | Certificate of Analysis | Mar 06, 2023 | M412873 |
D23141983 | Certificate of Analysis | Mar 06, 2023 | M412873 |
D23141988 | Certificate of Analysis | Mar 06, 2023 | M412873 |
D23142013 | Certificate of Analysis | Mar 06, 2023 | M412873 |
D23142026 | Certificate of Analysis | Mar 06, 2023 | M412873 |
D23142029 | Certificate of Analysis | Mar 06, 2023 | M412873 |
D23142034 | Certificate of Analysis | Mar 06, 2023 | M412873 |
D23142122 | Certificate of Analysis | Mar 06, 2023 | M412873 |
Solubility | Solubility (25°C) In vitro DMSO: 100 mg/mL (267.07 mM); |
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Sensitivity | Light sensitive |
DMSO(mg / mL) Max Solubility | 100 |
DMSO(mM) Max Solubility | 267.072617044574 |
Water(mg / mL) Max Solubility | -1 |