Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
M422113-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $241.90 |
TNF-α Selective Inhibitors | Activators | Antagonists
Synonyms | Myrislignan | 171485-39-5 | CHEMBL4085435 | (aR)-alpha-[(1S)-1-[2,6-Dimethoxy-4-(2-propen-1-yl)phenoxy]ethyl]-4-hydroxy-3-methoxybenzenemethanol | (-)-(1R,2S)-Myrislignan | DTXSID30333494 | HY-N0608 | BDBM50242967 | MFCD13195532 | s3261 | AKOS015909818 | AC-34668 | AS-77374 | CS-0 |
---|---|
Specifications & Purity | 10mM in DMSO |
Biochemical and Physiological Mechanisms | Myrislignan, a lignan isolated from Myristica fragrans Houtt, possesses anti-inflammatory activities. Myrislignan inhibits interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α). Myrislignan significantly inhibits the expressions of inducible NO syntha |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Product Description | Information Myrislignan, a lignan isolated fromMyristica fragrans Houtt, possesses anti-inflammatory activities. Myrislignan inhibitsinterleukin-6 (IL-6)andtumour necrosis factor-α (TNF-α). Myrislignan significantly inhibits the expressions ofinducible NO synthase (iNOS)andcyclooxygenase-2 (COX-2)dose-dependently in LPS-stimulated macrophage cells. Myrislignan inhibits theNF-κBsignalling pathway activation. Targets IL-6 ; TNF-α ; iNOS ; COX-2 ; NF-κB |
ALogP | 3.98 |
---|---|
HBD Count | 2 |
Rotatable Bond | 9 |
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
IUPAC Name | 4-[(1R,2S)-2-(2,6-dimethoxy-4-prop-2-enylphenoxy)-1-hydroxypropyl]-2-methoxyphenol |
---|---|
INCHI | InChI=1S/C21H26O6/c1-6-7-14-10-18(25-4)21(19(11-14)26-5)27-13(2)20(23)15-8-9-16(22)17(12-15)24-3/h6,8-13,20,22-23H,1,7H2,2-5H3/t13-,20-/m0/s1 |
InChi Key | ULZFTGWWPHYLGI-RBZFPXEDSA-N |
Canonical SMILES | CC(C(C1=CC(=C(C=C1)O)OC)O)OC2=C(C=C(C=C2OC)CC=C)OC |
Isomeric SMILES | C[C@@H]([C@@H](C1=CC(=C(C=C1)O)OC)O)OC2=C(C=C(C=C2OC)CC=C)OC |
PubChem CID | 21636106 |
Molecular Weight | 374.43 |
Enter Lot Number to search for COA:
DMSO(mg / mL) Max Solubility | 100 |
---|---|
DMSO(mM) Max Solubility | 267.072617044574 |
Water(mg / mL) Max Solubility | -1 |