Myrislignan - 10mM in DMSO, high purity , CAS No.171485-39-5

  • 10mM in DMSO
Item Number
M422113
Grouped product items
SKUSizeAvailabilityPrice Qty
M422113-1ml
1ml
Available within 4-8 weeks(?)
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$241.90

TNF-α Selective Inhibitors | Activators | Antagonists

Basic Description

SynonymsMyrislignan | 171485-39-5 | CHEMBL4085435 | (aR)-alpha-[(1S)-1-[2,6-Dimethoxy-4-(2-propen-1-yl)phenoxy]ethyl]-4-hydroxy-3-methoxybenzenemethanol | (-)-(1R,2S)-Myrislignan | DTXSID30333494 | HY-N0608 | BDBM50242967 | MFCD13195532 | s3261 | AKOS015909818 | AC-34668 | AS-77374 | CS-0
Specifications & Purity10mM in DMSO
Biochemical and Physiological MechanismsMyrislignan, a lignan isolated from Myristica fragrans Houtt, possesses anti-inflammatory activities. Myrislignan inhibits interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α). Myrislignan significantly inhibits the expressions of inducible NO syntha
Storage TempStore at -80°C
Shipped InIce chest + Ice pads
Product Description

Information

Myrislignan, a lignan isolated fromMyristica fragrans Houtt, possesses anti-inflammatory activities. Myrislignan inhibitsinterleukin-6 (IL-6)andtumour necrosis factor-α (TNF-α). Myrislignan significantly inhibits the expressions ofinducible NO synthase (iNOS)andcyclooxygenase-2 (COX-2)dose-dependently in LPS-stimulated macrophage cells. Myrislignan inhibits theNF-κBsignalling pathway activation.

Targets

IL-6 ; TNF-α ; iNOS ; COX-2 ; NF-κB

Product Properties

ALogP3.98
HBD Count2
Rotatable Bond9

Associated Targets(non-human)

Toxoplasma gondii (4585 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
nanA Sialidase A (49 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 4-[(1R,2S)-2-(2,6-dimethoxy-4-prop-2-enylphenoxy)-1-hydroxypropyl]-2-methoxyphenol
INCHI InChI=1S/C21H26O6/c1-6-7-14-10-18(25-4)21(19(11-14)26-5)27-13(2)20(23)15-8-9-16(22)17(12-15)24-3/h6,8-13,20,22-23H,1,7H2,2-5H3/t13-,20-/m0/s1
InChi Key ULZFTGWWPHYLGI-RBZFPXEDSA-N
Canonical SMILES CC(C(C1=CC(=C(C=C1)O)OC)O)OC2=C(C=C(C=C2OC)CC=C)OC
Isomeric SMILES C[C@@H]([C@@H](C1=CC(=C(C=C1)O)OC)O)OC2=C(C=C(C=C2OC)CC=C)OC
PubChem CID 21636106
Molecular Weight 374.43

Certificates

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Chemical and Physical Properties

DMSO(mg / mL) Max Solubility100
DMSO(mM) Max Solubility267.072617044574
Water(mg / mL) Max Solubility-1

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