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Mz1 - ≥98%, high purity , CAS No.1797406-69-9, Inhibitor of bromodomain containing 4

Moligand™
≥98%

CAS#: 1797406-69-9
Formula: C₄₉H₆₀ClN₉O₈S₂
Molecular Weight: 1002.64
PubChem CID: 122201421

Item Number

M275142

Grouped product items
SKU	Size	Availability	Price
M275142-1mg	1mg	In stock	$58.90
M275142-500μg	500μg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$35.90
M275142-5mg	5mg	In stock	$197.90
M275142-10mg	10mg	In stock	$375.90
M275142-25mg	25mg	In stock	$541.90
M275142-50mg	50mg	In stock	$706.90
M275142-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,272.90

(+)-JQ1 based PROTAC that selectively degrades BRD4

View related series

bromodomain containing 4 Inhibitor

Specifications & Purity

≥98%

Source

Synthetic

Storage Temp

Store at -20°C

Shipped In

Dry ice

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of bromodomain containing 4

Product Description

Shipped at 4°C. Store at -20°C.

Names and Identifiers

IUPAC Name	(2S,4R)-1-[(2S)-2-[[2-[2-[2-[2-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]ethoxy]ethoxy]ethoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
INCHI	InChI=1S/C49H60ClN9O8S2/c1-28-30(3)69-48-41(28)42(33-12-14-35(50)15-13-33)54-37(45-57-56-31(4)59(45)48)23-39(61)51-16-17-65-18-19-66-20-21-67-26-40(62)55-44(49(5,6)7)47(64)58-25-36(60)22-38(58)46(63)52-24-32-8-10-34(11-9-32)43-29(2)53-27-68-43/h8-15,27,36-38,44,60H,16-26H2,1-7H3,(H,51,61)(H,52,63)(H,55,62)/t36-,37+,38+,44-/m1/s1
InChi Key	PTAMRJLIOCHJMQ-PYNGZGNASA-N
Canonical SMILES	CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)NCCOCCOCCOCC(=O)NC(C(=O)N4CC(CC4C(=O)NCC5=CC=C(C=C5)C6=C(N=CS6)C)O)C(C)(C)C)C7=CC=C(C=C7)Cl)C
Isomeric SMILES	CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)NCCOCCOCCOCC(=O)N[C@H](C(=O)N4C[C@@H](C[C@H]4C(=O)NCC5=CC=C(C=C5)C6=C(N=CS6)C)O)C(C)(C)C)C7=CC=C(C=C7)Cl)C
PubChem CID	122201421
Molecular Weight	1002.64

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7 results found

Lot Number	Certificate Type	Date	Item
A2208128	Certificate of Analysis	Oct 21, 2022	M275142
A2208129	Certificate of Analysis	Oct 21, 2022	M275142
A2208130	Certificate of Analysis	Oct 21, 2022	M275142
A2208131	Certificate of Analysis	Oct 21, 2022	M275142
A2208158	Certificate of Analysis	Oct 21, 2022	M275142
A2208159	Certificate of Analysis	Oct 21, 2022	M275142
A2208160	Certificate of Analysis	Oct 21, 2022	M275142

References

1. Chan KH, Zengerle M, Testa A, Ciulli A. (2018) Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds.. J Med Chem, 61 (2): (504-513). [PMID:28595007]
2. Nantajit D et al.. (2022) EGFR-induced suppression of HPV E6/E7 is mediated by microRNA-9-5p silencing of BRD4 protein in HPV-positive head and neck squamous cell carcinoma.. Cell Death Dis, 13 (11): (921). [PMID:36333293]

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Mz1 - ≥98%, high purity , CAS No.1797406-69-9, Inhibitor of bromodomain containing 4

Basic Description

Associated Targets

BRD4 Tchem Bromodomain-containing protein 4 1 Activities