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N-(1-Naphthalenylsulfonyl)-Ile-Trp-aldehyde , CAS No.161709-56-4

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N-(1-Naphthalenylsulfonyl)-Ile-Trp-aldehyde , CAS No.161709-56-4

CAS#: 161709-56-4
Formula: C₂₇H₂₉N₃O₄S
Molecular Weight: 491.6
PubChem CID: 9957276

Item Number

N336626

Grouped product items
SKU	Size	Availability	Price	Qty
N336626-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$142.90
N336626-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$472.90

an inhibitor of cathepsin L

Basic Description

Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	N-(1-Naphthalenylsulfonyl)-Ile-Trp-aldehyde is a potent, reversible, and selective inhibitor of human cathepsin L (IC\|50\|=1.9nM). Inhibits release of Ca\|2+\|and hydroxyproline from bone\|in vitro\|.

Product Properties

pKa	pKa: 9.25 (Predicted)

Associated Targets(Human)

HL-60 (67320 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CAPN9 Tbio Calpain-9 (15 Activities)

Discover Target: CAPN9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Trypanosoma brucei brucei (13300 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

H4 (48 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(2S,3S)-N-[(2S)-1-(1H-indol-3-yl)-3-oxopropan-2-yl]-3-methyl-2-(naphthalen-1-ylsulfonylamino)pentanamide
INCHI	InChI=1S/C27H29N3O4S/c1-3-18(2)26(30-35(33,34)25-14-8-10-19-9-4-5-12-23(19)25)27(32)29-21(17-31)15-20-16-28-24-13-7-6-11-22(20)24/h4-14,16-18,21,26,28,30H,3,15H2,1-2H3,(H,29,32)/t18-,21-,26-/m0/s1
InChi Key	FFPHAWVFZQFOJA-JCWFFFCVSA-N
Canonical SMILES	CCC(C)C(C(=O)NC(CC1=CNC2=CC=CC=C21)C=O)NS(=O)(=O)C3=CC=CC4=CC=CC=C43
Isomeric SMILES	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C=O)NS(=O)(=O)C3=CC=CC4=CC=CC=C43
PubChem CID	9957276
Molecular Weight	491.6

Certificates

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Chemical and Physical Properties

Solubility	Soluble in DMSO (5 mg/ml), and ethyl acetate (50 mg/ml).
Refractive Index	n20D1.64 (Predicted)
Melt Point(°C)	323.46° C (Predicted)

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