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E3 ubiquitin ligase components
N-(2,5-Dioxopyrrolidin-3-yl)cinnamamide , CAS No.N609419, cereblon

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N-(2,5-Dioxopyrrolidin-3-yl)cinnamamide , CAS No.N609419, cereblon

Moligand™

PubChem CID: 139593560

Item Number

N609419

Grouped product items
SKU	Size	Availability	Price	Qty
N609419-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
N609419-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

cereblon

Basic Description

Synonyms	compound 7f
Specifications & Purity	Moligand™
Grade	Moligand™
Mechanism of action	cereblon

Associated Targets(Human)

CRBN Tclin Protein cereblon (0 Activities)

Discover Target: CRBN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CSNK1A1 Tchem Cereblon/Casein kinase I alpha (35 Activities)

Discover Target: CSNK1A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CRBN Tclin Cereblon/Aiolos (164 Activities)

Discover Target: CRBN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Cereblon isoform 4 (52 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	N-(2,5-Dioxopyrrolidin-3-yl)cinnamamide
INCHI	InChI=1S/C13H12N2O3/c16-11(7-6-9-4-2-1-3-5-9)14-10-8-12(17)15-13(10)18/h1-7,10H,8H2,(H,14,16)(H,15,17,18)/b7-6+
InChi Key	NSEUGMATEWSNTO-VOTSOKGWSA-N
Canonical SMILES	O=C(NC1CC(=O)NC1=O)/C=C/c1ccccc1
Isomeric SMILES	C1C(C(=O)NC1=O)NC(=O)/C=C/C2=CC=CC=C2
PubChem CID	139593560

Database links

PubChem CID	139593560

Certificates

Certificate of Analysis(COA)

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References

1. Heim C, Pliatsika D, Mousavizadeh F, Bär K, Hernandez Alvarez B, Giannis A, Hartmann MD. (2019) De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives.. J Med Chem, 62 (14): (6615-6629). [PMID:31251063]

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