Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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M106464-5g | 5g | In stock | $59.90 | |
M106464-25g | 25g | In stock | $229.90 | |
M106464-100g | 100g | In stock | $827.90 |
Short acting reducing agent
Synonyms | Tiopronine | AC-2087 | Acadione; Capen; Epatiol; Vincol | A-MERCAPTOPROPIONYL GLYCINE | SW219206-1 | DTXCID803678 | Mucolysin | N-(2-Mercaptopropionyl)glycine | TIOPRONIN [JAN] | Tiopronin Base | AKOS015895408 | BDBM50020805 | N-(2-mercaptopropanoyl)glyci |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Short acting reducing agent. Shows anticystinuric and hepatoprotective effects in vivo . Orally active. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Mechanism of action | Reducing agent |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Controls the rate of cystine precipitation and excretion Tiopronin is a prescription thiol drug used to control the rate of cystine precipitation and excretion in the disease cystinuria. Target: Others Tiopronin is used primarily for cystinuria and is well known in the cystinuric community. Depending on the severity of a person's cystinuria, tiopronin may be taken for life, possibly starting in early childhood. It may also be used for Wilson's disease (an overload of copper in the body), and certain types of rare arthritis, though tiopronin is not an anti-inflammatory. Tiopronin is also sometimes used as a stabilizing agent for metal nanoparticles. The thiol group binds to the nanoparticles, preventing coagulation . |
ALogP | -0.1 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 2-(2-sulfanylpropanoylamino)acetic acid |
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INCHI | InChI=1S/C5H9NO3S/c1-3(10)5(9)6-2-4(7)8/h3,10H,2H2,1H3,(H,6,9)(H,7,8) |
InChi Key | YTGJWQPHMWSCST-UHFFFAOYSA-N |
Canonical SMILES | CC(C(=O)NCC(=O)O)S |
Isomeric SMILES | CC(C(=O)NCC(=O)O)S |
PubChem CID | 5483 |
Molecular Weight | 163.19 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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L2031304 | Certificate of Analysis | Oct 12, 2024 | M106464 |
H2430073 | Certificate of Analysis | Sep 07, 2024 | M106464 |
J1523053 | Certificate of Analysis | Jul 07, 2023 | M106464 |
I2212062 | Certificate of Analysis | Aug 01, 2022 | M106464 |
I2212063 | Certificate of Analysis | Aug 01, 2022 | M106464 |
I2212064 | Certificate of Analysis | Aug 01, 2022 | M106464 |
Solubility | Soluble in DMSO (32 mg/ml at 25 °C), water (32 mg/ml at 25 °C), ethanol (32 mg/ml at 25 °C), and methanol. |
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Melt Point(°C) | 98°C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H302:Harmful if swallowed |
Precautionary Statements | P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. |
Merck Index | 9453 |
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14. Jian-qing Wang,Yu-hong Zou,Cheng Huang,Chao Lu,Lei Zhang,Yong Jin,Xiong-wen Lü,Li-ping Liu,Jun Li. (2012-05-01) Protective effects of tiopronin against high fat diet-induced non-alcoholic steatohepatitis in rats.. Acta pharmacologica Sinica, 33 ((6)): (791-797). [PMID:22543705] |
15. Jung Ah Lee,Jin Woo Choi,Jang Hyeok In,Hong Soo Jung,Yong Shin Kim,Yeon Soo Jeon,Yoo Jin Kang,Dae Woo Kim,Yong Gul Lim,Jae Hee Park,Jin Deok Joo. (2012-05-09) Hepatic ischemic preconditioning provides protection against distant renal ischemia and reperfusion injury in mice.. Journal of Korean medical science, 27 ((5)): (547-552). [PMID:22563222] |
16. Ryan P Taylor,Joseph W Starnes. (2012-09-08) Reactive oxygen species are not a required trigger for exercise-induced late preconditioning in the rat heart.. American journal of physiology. Regulatory, integrative and comparative physiology, 303 ((9)): (R968-R974). [PMID:22955056] |
17. Zhanguang Chen,Zhen Wang,Junhui Chen,Wenhua Gao. (2012-09-13) Label-free fluorescence turn on detection of tiopronin with tunable dynamic range based on the ensemble of Alizarin Red S/copper ion.. Talanta, 99 (774-779). [PMID:22967623] |
18. Mildred Quintana,Marek Grzelczak,Konstantinos Spyrou,Bart Kooi,Sara Bals,Gustaaf Van Tendeloo,Petra Rudolf,Maurizio Prato. (2012-10-24) Production of large graphene sheets by exfoliation of graphite under high power ultrasound in the presence of tiopronin.. Chemical communications (Cambridge, England), 48 ((100)): (12159-12161). [PMID:23091819] |
19. Hulya Nalcacioglu,Ender Ozden,Gurkan Genc,Y Kamil Yakupoglu,Saban Sarikaya,Ozan Ozkaya. (2012-10-27) An uncommon cause of acute kidney injury in young children: cystinuria.. Journal of pediatric urology, 9 ((1)): (e58-e63). [PMID:23099233] |
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