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Home Applications Targets Kinases TK:Tyrosine kinase N-[5-[3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-ethyl-2-oxo-1,6-naphthyridin-7-yl]-4-methoxy-2-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]phenyl]but-2-ynamide , CAS No.N609500, Inhibitor of fibroblast growth factor receptor 4
N-[5-[3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-ethyl-2-oxo-1,6-naphthyridin-7-yl]-4-methoxy-2-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]phenyl]but-2-ynamide , CAS No.N609500, Inhibitor of fibroblast growth factor receptor 4
Basic Description Specifications & Purity Moligand™ Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of fibroblast growth factor receptor 4
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name N-[5-[3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-ethyl-2-oxo-1,6-naphthyridin-7-yl]-4-methoxy-2-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]phenyl]but-2-ynamide INCHI InChI=1S/C34H32Cl2N4O6/c1-6-8-30(41)38-24-11-21(27(43-3)13-26(24)40-16-20-10-19(40)17-46-20)23-12-25-18(15-37-23)9-22(34(42)39(25)7-2)31-32(35)28(44-4)14-29(45-5)33(31)36/h9,11-15,19-20H,7,10,16-17H2,1-5H3,(H,38,41)/t19-,20-/m1/s1 InChi Key VDIDNMGZRIMBKL-WOJBJXKFSA-N Canonical SMILES [C@H]12OC[C@H](N(C1)c1c(cc(c(c1)OC)c1ncc3cc(c(=O)n(c3c1)CC)c1c(c(cc(c1Cl)OC)OC)Cl)NC(=O)C#CC)C2 Isomeric SMILES CCN1C2=CC(=NC=C2C=C(C1=O)C3=C(C(=CC(=C3Cl)OC)OC)Cl)C4=CC(=C(C=C4OC)N5C[C@H]6C[C@@H]5CO6)NC(=O)C#CC PubChem CID 153531813
References 1. Zhang X, Wang Y, Ji J, Si D, Bao X, Yu Z, Zhu Y, Zhao L, Li W, Liu J. (2022) Discovery of 1,6-Naphthyridin-2(1H )-one Derivatives as Novel, Potent, and Selective FGFR4 Inhibitors for the Treatment of Hepatocellular Carcinoma.. J Med Chem, 71 (13): (1755-70). [PMID:35635004 ] [10.1021/acs.jmedchem.1c01977 ]
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