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Home Applications Targets Kinases Other protein kinases N-[5-[[3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-methylphenyl]acetamide , CAS No.N608846, Inhibitor of casein kinase 2; alpha 1 polypeptide subunit;Inhibitor of dual specificity tyrosine phosphorylation regulated kinase 3;Inhibitor of homeodomain interacting protein kinase 2;Inhibitor of Pim-3 proto-oncogene; serine/threonine kinase
N-[5-[[3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-methylphenyl]acetamide , CAS No.N608846, Inhibitor of casein kinase 2; alpha 1 polypeptide subunit;Inhibitor of dual specificity tyrosine phosphorylation regulated kinase 3;Inhibitor of homeodomain interacting protein kinase 2;Inhibitor of Pim-3 proto-oncogene; serine/threonine kinase
Basic Description Synonyms compound 1a Specifications & Purity Moligand™ Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of casein kinase 2; alpha 1 polypeptide subunit;Inhibitor of dual specificity tyrosine phosphorylation regulated kinase 3;Inhibitor of homeodomain interacting protein kinase 2;Inhibitor of Pim-3 proto-oncogene; serine/threonine kinase
Names and Identifiers IUPAC Name N-[5-[[3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-methylphenyl]acetamide INCHI InChI=1S/C19H19N7O/c1-11-3-4-15(7-16(11)22-12(2)27)23-17-8-18(24-14-5-6-14)26-19(25-17)13(9-20)10-21-26/h3-4,7-8,10,14,24H,5-6H2,1-2H3,(H,22,27)(H,23,25) InChi Key GDSQVLMYYCNAGP-UHFFFAOYSA-N Canonical SMILES N#Cc1cnn2c1nc(Nc1ccc(c(c1)NC(=O)C)C)cc2NC1CC1 Isomeric SMILES CC1=C(C=C(C=C1)NC2=NC3=C(C=NN3C(=C2)NC4CC4)C#N)NC(=O)C PubChem CID 72163809
References 1. Dowling JE, Alimzhanov M, Bao L, Block MH, Chuaqui C, Cooke EL, Denz CR, Hird A, Huang S, Larsen NA et al. . (2013) Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo.. ACS Med Chem Lett, 4 (8): (800-5). [PMID:24900749 ]
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