N-[5-[6-(2,6-dichloro-4-methoxyphenyl)-2-pyrazin-2-ylpyrimidin-4-yl]-1,3-thiazol-2-yl]acetamide , CAS No.N609132, Inhibitor of LIM domain kinase 1;Inhibitor of LIM domain kinase 2;Inhibitor of testis associated actin remodelling kinase 1;Inhibitor of testis associated actin remodelling kinase 2

Item Number
N609132
Grouped product items
SKUSizeAvailabilityPrice Qty
N609132-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
N609132-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90

Basic Description

Specifications & PurityMoligand™
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of LIM domain kinase 1;Inhibitor of LIM domain kinase 2;Inhibitor of testis associated actin remodelling kinase 1;Inhibitor of testis associated actin remodelling kinase 2

Associated Targets(Human)

TESK1 Tchem Dual specificity testis-specific protein kinase 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
LIMK1 Tchem LIM domain kinase 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
LIMK2 Tchem LIM domain kinase 2 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TESK2 Tchem Dual specificity testis-specific protein kinase 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
LIMK1 Tchem LIM domain kinase 1 (2329 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TESK1 Tchem Dual specificity testis-specific protein kinase 1 (550 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LIMK2 Tchem LIM domain kinase 2 (949 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name N-[5-[6-(2,6-dichloro-4-methoxyphenyl)-2-pyrazin-2-ylpyrimidin-4-yl]-1,3-thiazol-2-yl]acetamide
INCHI InChI=1S/C20H14Cl2N6O2S/c1-10(29)26-20-25-9-17(31-20)14-7-15(18-12(21)5-11(30-2)6-13(18)22)28-19(27-14)16-8-23-3-4-24-16/h3-9H,1-2H3,(H,25,26,29)
InChi Key XACSASLXEAYEEO-UHFFFAOYSA-N
Canonical SMILES COc1cc(Cl)c(c(c1)Cl)c1cc(nc(n1)c1cnccn1)c1cnc(s1)NC(=O)C
Isomeric SMILES CC(=O)NC1=NC=C(S1)C2=CC(=NC(=N2)C3=NC=CN=C3)C4=C(C=C(C=C4Cl)OC)Cl
PubChem CID 58688563

Certificates

Certificate of Analysis(COA)

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Related Documents

References

1. Røsok O, Pedeutour F, Ree AH, Aasheim HC.  (1999)  Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis..  Genomics,  61  (1): (44-54).  [PMID:10512679] [10.1021/op500134e]
2. Toshima J, Toshima JY, Takeuchi K, Mori R, Mizuno K.  (2001)  Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells..  J Biol Chem,  276  (33): (31449-58).  [PMID:11418599] [10.1021/op500134e]
3. Johne C, Matenia D, Li XY, Timm T, Balusamy K, Mandelkow EM.  (2008)  Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton..  Mol Biol Cell,  19  (4): (1391-403).  [PMID:18216281] [10.1021/op500134e]
4. He L, Seitz SP, Trainor GL, Tortolani D, Vaccaro W, Poss M, Tarby CM, Tokarski JS, Penhallow B, Hung CY et al..  (2012)  Modulation of cofilin phosphorylation by inhibition of the Lim family kinases..  Bioorg Med Chem Lett,  22  (18): (5995-8).  [PMID:22902653] [10.1021/op500134e]
5. Arber S, Barbayannis FA, Hanser H, Schneider C, Stanyon CA, Bernard O, Caroni P.  (1998)  Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase..  Nature,  393  (6687): (805-9).  [PMID:9655397] [10.1021/op500134e]
6. Yang N, Higuchi O, Ohashi K, Nagata K, Wada A, Kangawa K, Nishida E, Mizuno K.  (1998)  Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization..  Nature,  393  (6687): (809-12).  [PMID:9655398] [10.1021/op500134e]

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