Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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N136431-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $43.90 | |
N136431-100mg | 100mg | In stock | $137.90 | |
N136431-500mg | 500mg | In stock | $273.90 | |
N136431-1g | 1g | In stock | $496.90 |
CaM and myosin light chain kinase inhibitor
Synonyms | ALEXIDINE [MART.] | N-(6-aminohexyl)-5-chloronaphthalene-1-sulfonamide;hydrochloride | NCGC00178278-01 | W-7, Hydrochloride - CAS 61714-27-0 | SMR000326845 | C16092 | AKOS024457749 | N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULPHONAMIDE HYDROCHLORIDE | SPEC |
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Specifications & Purity | ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | CaM and myosin light chain kinase inhibitor (IC 50 values are 28 and 51 μM for CaM-dependent PDE activity and myosin light chain kinase respectively). W-5 , W-12 and W-13 analog. Shows antiproliferative effects. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | W-7 has been reported to be a calmodulin (CaM) antagonist that inhibits Ca2+/calmodulin-regulated enzyme activities. Injection of murine tails with W-7 has demonstrated this agents ability to decrease tolerance to antinociceptive effects, therefore, CaM and its dependent pathways have demonstrated the capacity to play a role in antinociceptive agent tolerance processes. This cell permeable compound has been found to inhibit proliferation of hamster ovary K1 cells. W-7 has also been noted to bind troponin C in the presence of Ca2+ and inhibit striated muscle contractions. Application N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride has been used to study its effect of on coated pit staining. |
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IUPAC Name | N-(6-aminohexyl)-5-chloronaphthalene-1-sulfonamide;hydrochloride |
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INCHI | InChI=1S/C16H21ClN2O2S.ClH/c17-15-9-5-8-14-13(15)7-6-10-16(14)22(20,21)19-12-4-2-1-3-11-18;/h5-10,19H,1-4,11-12,18H2;1H |
InChi Key | OMMOSRLIFSCDBL-UHFFFAOYSA-N |
Canonical SMILES | C1=CC2=C(C=CC=C2Cl)C(=C1)S(=O)(=O)NCCCCCCN.Cl |
Isomeric SMILES | C1=CC2=C(C=CC=C2Cl)C(=C1)S(=O)(=O)NCCCCCCN.Cl |
WGK Germany | 3 |
PubChem CID | 124887 |
Molecular Weight | 377.33 |
Beilstein | 6030170 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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G2304968 | Certificate of Analysis | May 04, 2023 | N136431 |
G2304969 | Certificate of Analysis | May 04, 2023 | N136431 |
G2304970 | Certificate of Analysis | May 04, 2023 | N136431 |
G2304974 | Certificate of Analysis | May 04, 2023 | N136431 |
G2304975 | Certificate of Analysis | May 04, 2023 | N136431 |
G2304976 | Certificate of Analysis | May 04, 2023 | N136431 |
H2406072 | Certificate of Analysis | May 04, 2023 | N136431 |
E2127046 | Certificate of Analysis | Apr 10, 2023 | N136431 |
C2303179 | Certificate of Analysis | Mar 11, 2023 | N136431 |
C1905041 | Certificate of Analysis | Oct 21, 2022 | N136431 |
Solubility | Soluble in water (Partly miscible), methanol, 100% ethanol (10 mg/ml)(warm), DMSO (25 mg/ml), DMF, ethylene glycol, and 50% ethanol/water (20 mg/ml). |
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Sensitivity | Heat Sensitive |
Melt Point(°C) | 222 °C |
WGK Germany | 3 |
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1. Zhang H et al.. (2022) Signaling pathways involved in NMDA-induced suppression of M-channels in corticotropin-releasing hormone neurons in central amygdala.. J Neurochem, 161 (6): (478-491). [PMID:35583089] |