CaM and myosin light chain kinase inhibitor (IC 50 values are 28 and 51 μM for CaM-dependent PDE activity and myosin light chain kinase respectively). W-5 , W-12 and W-13 analog. Shows antiproliferative effects.
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
W-7 has been reported to be a calmodulin (CaM) antagonist that inhibits Ca2+/calmodulin-regulated enzyme activities. Injection of murine tails with W-7 has demonstrated this agents ability to decrease tolerance to antinociceptive effects, therefore, CaM and its dependent pathways have demonstrated the capacity to play a role in antinociceptive agent tolerance processes. This cell permeable compound has been found to inhibit proliferation of hamster ovary K1 cells. W-7 has also been noted to bind troponin C in the presence of Ca2+ and inhibit striated muscle contractions. A calmodulin (CaM) antagonist and antiproliferative agent.
Application
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride has been used to study its effect of on coated pit staining.
1.Bin Zhang, Xueying Li, Xiuhong Li, Zhigang Lu, Xiaona Cai, Qing Ou Yang, Pengda Ma, Juane Dong. (2020) Lipopolysaccharide Enhances Tanshinone Biosynthesis via a Ca2+-Dependent Manner in Salvia miltiorrhiza Hairy Roots. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21 (24):(9576). [PMID:33339149][10.3390/ijms21249576]
References
1.Zhang H et al.. (2022) Signaling pathways involved in NMDA-induced suppression of M-channels in corticotropin-releasing hormone neurons in central amygdala.. J Neurochem, 161 (6):(478-491). [PMID:35583089]
2.Bin Zhang, Xueying Li, Xiuhong Li, Zhigang Lu, Xiaona Cai, Qing Ou Yang, Pengda Ma, Juane Dong. (2020) Lipopolysaccharide Enhances Tanshinone Biosynthesis via a Ca2+-Dependent Manner in Salvia miltiorrhiza Hairy Roots. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21 (24):(9576). [PMID:33339149][10.3390/ijms21249576]
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G2304968