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N-(9-Cyclopropyl-1-oxononyl)-N-hydroxy-β-alanine - >80.0%(HPLC), high purity , CAS No.1453071-47-0
Selective KDM2/7 inhibitor
Basic Description Synonyms AKOS025142046 | SCHEMBL20493040 | beta-Alanine, N-(9-cyclopropyl-1-oxononyl)-N-hydroxy- | MFCD28166486 | 1453071-47-0 | 3-[9-cyclopropylnonanoyl(hydroxy)amino]propanoic acid | 3-(9-CYCLOPROPYL-N-HYDROXYNONANAMIDO)PROPANOIC ACID | A16373 | beta-Alanine,N-( Specifications & Purity ≥80%(HPLC) Biochemical and Physiological Mechanisms Selective histone demethylase KDM2/7 subfamily inhibitor (IC50values are 0.2, 1.2, 6.8, 55, 83, >100 and >120μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). Inhibits growth of HeLa and KYSE-150 cancer cellsin vitro. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 3-[9-cyclopropylnonanoyl(hydroxy)amino]propanoic acid INCHI InChI=1S/C15H27NO4/c17-14(16(20)12-11-15(18)19)8-6-4-2-1-3-5-7-13-9-10-13/h13,20H,1-12H2,(H,18,19) InChi Key NEHSERYKENINRH-UHFFFAOYSA-N Canonical SMILES C1CC1CCCCCCCCC(=O)N(CCC(=O)O)O Isomeric SMILES C1CC1CCCCCCCCC(=O)N(CCC(=O)O)O PubChem CID 71735843 Molecular Weight 285.38 Reaxy-Rn 24042959
Chemical and Physical Properties Solubility Solvent:1eq. NaOH, Max Conc. mg/mL: 28.54, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 28.54, Max Conc. mM: 100 Sensitivity Heat Sensitive Melt Point(°C) 87°C(lit.)
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
Precautionary Statements P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P264: Wash hands [and …] thoroughly after handling.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
Reaxy-Rn 24042959
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